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EFFECTS OF SELECTIVE ADVANTAGE OF HbS OVER HbA IN THE TRANSMISSION DYNAMICS OF SICKLE CELL ANAEMIA

Author

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  • JEAN M. TCHUENCHE

    (Department of Mathematical Sciences, University of Agriculture, PMB 2240, Abeokuta, Nigeria)

Abstract

Despite rising concern over the biology of Sickle Cell Anaemia (SCA), no general modeling approach has considered the effects of the selective advantage of Haemoglobin S (HbS) over Haemoglobin (HbA). This paper develops a theoretical framework and demonstrates mathematically that mating between the three different genotypic groups, namely: normal AA, carriers AS and sicklers SS, does not yield equal probabilities of having neonates of these classes.

Suggested Citation

  • Jean M. Tchuenche, 2005. "EFFECTS OF SELECTIVE ADVANTAGE OF HbS OVER HbA IN THE TRANSMISSION DYNAMICS OF SICKLE CELL ANAEMIA," Advances in Complex Systems (ACS), World Scientific Publishing Co. Pte. Ltd., vol. 8(01), pages 1-5.
    • Handle: RePEc:wsi:acsxxx:v:08:y:2005:i:01:n:s0219525905000300
    DOI: 10.1142/S0219525905000300
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