IDEAS home Printed from https://ideas.repec.org/a/tec/bioche/ojs13325.html

Retrosynthetic Analysis of Centratherolide A

Author

Listed:
  • Nathan S. Lee

    (Philips Academy Andover, 7 Chapel Ave, Andover, MA 01810, USA)

Abstract

Centratherolide A is small and permeable, yet it can cause selective irreversible reactions to proteins, including topoisomerase-3β(TOP3B), the only dual RNA and DNA topoisomerase found in humans. Centratherolide A is mainly cytotoxic because of its α-methylene-γ-lactone ring, a potent Michael Acceptor present in their family of Furanoheliangolides and sesquiterpene lactones. Through the common atom analysis, oxidation level analysis, Michael Addition, and common carbon relationships, Centratherolide A was able to be broken down into 7 parts. Trisecting the main chain seems more plausible than bisecting. Further understanding of different R groups and variations propose a possibility of cytotoxicity against other diseases and cancers.

Suggested Citation

  • Nathan S. Lee, 2025. "Retrosynthetic Analysis of Centratherolide A," Technium BioChemMed: Journal of Multidisciplinary Research, Biology, Chemistry and Medicine ISSN 2734 - 7990, Technium Science, vol. 13, pages 227-236, November.
    • Handle: RePEc:tec:bioche:ojs:13325
    DOI: 10.47577/biochemmed.v13i.13325
    as

    Download full text from publisher

    File URL: https://techniumscience.com/index.php/biochemmed/article/view/13325
    Download Restriction: no
    File URL: https://libkey.io/10.47577/biochemmed.v13i.13325?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:tec:bioche:ojs:13325. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Anna Maria Golita (email available below). General contact details of provider: .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.