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Novel drug combinations suggested for treating pancreatic cancer

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  • Meyer Elazar

    (214 Haalon St., Matta, Israel)

Abstract

Pancreatic cancer (PC) is a type of gastrointestinal tumor with poor anticipation and high level of death rate, being a fatal disease in which the overall 5-year survival rate is less than 4%1. PC poorly responds to most chemotherapeutic agents and the main current systemic chemotherapy treatments for patients with advanced disease are the drug combinations FOLFIRINOX and gemcitabine plus nanoparticle albumin-bound (nab)-paclitaxel (Abraxane). Therefore, there is a profound world-wide unmet medical need for new drug combination treatments having significant positive impact on the survival and day-to-day functioning of PC patients. It is suggested herein that treatment of drug combinations of bevacizumab plus bortezomib or dacarbazine and decitabine and optionally interferon α can be beneficial for patients suffering from locally advanced and metastatic PC, subject to creating predictive models to determine possible drug resistance and receiving positive results in clinical trials.

Suggested Citation

  • Meyer Elazar, 2024. "Novel drug combinations suggested for treating pancreatic cancer," Technium BioChemMed: Journal of Multidisciplinary Research, Biology, Chemistry and Medicine ISSN 2734 - 7990, Technium Science, vol. 9, pages 41-47, September.
    • Handle: RePEc:tec:bioche:ojs:11739
    DOI: 10.47577/biochemmed.v9i.11739
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