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Efflux Pump Inhibitors as a Broad-Spectrum Strategy to Combat Multidrug Resistance Acenitobacter Baumanii

Author

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  • Ayat Alaaeldin Abdulazeez

    (Department of Basic Sciences, College of Dentistry, University of Kerbala, Kerbala, Iraq)

  • Zainab Salim Jaafar

    (Department of Bioinformatics, College of Biomedical Informatics, University of Information Technology and Communications, Baghdad, Iraq.)

Abstract

The World Health Organization (WHO) identifies A. baumannii as one of the most resistant pathogens. Over the past few years, there has been a significant rise in its resistance to a wide array of antibiotics. Multidrug resistance is attributed to several mechanisms, with efflux pumps being the most notable. Recently, the development of new treatment strategies to tackle A. baumannii infections has shown great promise. This review focuses on the various families of efflux pumps in A. baumannii and explores innovative therapeutic options that have emerged over the past four years. Specifically, we emphasize synthetic and natural efflux pump inhibitors (EPIs), nanoparticles, bacteriophage therapy, and antimicrobial peptides (AMPs) as part of these novel strategies.

Suggested Citation

  • Ayat Alaaeldin Abdulazeez & Zainab Salim Jaafar, 2024. "Efflux Pump Inhibitors as a Broad-Spectrum Strategy to Combat Multidrug Resistance Acenitobacter Baumanii," Technium BioChemMed: Journal of Multidisciplinary Research, Biology, Chemistry and Medicine ISSN 2734 - 7990, Technium Science, vol. 10, pages 11-23, October.
    • Handle: RePEc:tec:bioche:ojs:11738
    DOI: 10.47577/biochemmed.v10i.11738
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