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Photothermal therapy of cancer cells enhanced by glutathione (GSH) modified small-sized gold nanoparticles

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  • Lamyaa F. A. AL-Barram
  • Selma M. H. AL-Jawad
  • Ali A. Taha
  • Natheer Jamal Imran

Abstract

Small-sized gold nanoparticles (∼3nm) coated with Glutathione (GSH) ligand have designed as an active agent in photothermal therapy (PTT). GSH is pH-sensitive surface that have a fast response property to the variation in pH conditions, especially between normal (∼7.4) and cancer cell (6–6.5), that help the evaluation of the target and toxic effect of the cancer rather than normal cells. Results revealed considerable toxic effects of GSH-AuNPs accumulation in cancer cells for both green and NIR laser irradiation. The GSH-AuNPs represent promising agents for developing the safety issues of photothermal cancer treatment by; the selective targeting of the cancer rather than normal cells, reducing the NPs toxicity by their size overlapping with the renal clearance barrier of kidney filtration (~5.5 nm), and promoting the photothermal performance in the NIR region, in which light penetration into deep cancer regions are more interested.

Suggested Citation

  • Lamyaa F. A. AL-Barram & Selma M. H. AL-Jawad & Ali A. Taha & Natheer Jamal Imran, 2020. "Photothermal therapy of cancer cells enhanced by glutathione (GSH) modified small-sized gold nanoparticles," Journal of Electromagnetic Waves and Applications, Taylor & Francis Journals, vol. 34(18), pages 2467-2487, December.
    • Handle: RePEc:taf:tewaxx:v:34:y:2020:i:18:p:2467-2487
    DOI: 10.1080/09205071.2020.1822759
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