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Assessing Cognitive Therapy Instead Of Neuroleptics: Rationale, study design and sample characteristics of the ACTION trial

Author

Listed:
  • Anthony Morrison
  • Melissa Wardle
  • Paul Hutton
  • Linda Davies
  • Graham Dunn
  • Alison Brabban
  • Rory Byrne
  • Laura Drage
  • Helen Spencer
  • Douglas Turkington

Abstract

Aims: Recent evidence regarding over-estimation of the efficacy of antipsychotics and under-estimation of their toxicity, as well as emerging data regarding alternative treatment options, suggest it may be time to introduce patient choice. However, only a small number of studies have reported on the efficacy of interventions for psychological interventions such as cognitive therapy. Early results suggest that cognitive therapy may be an effective, well-tolerated treatment for people who choose not to take antipsychotics. We report on the rationale and design for a multi-site randomised, controlled trial of cognitive therapy for people with a schizophrenia spectrum diagnosis who choose not to take antipsychotics. Methods: The study employs a single-blind design in which all participants receive treatment as usual, and half are randomised to up to 30 sessions of cognitive therapy for up to 9 months. Participants will be followed-up for a minimum of 9 months and to a maximum of 18 months. Results: We report the characteristics of the final sample at baseline (N = 74). Conclusions: Our study aims to expand the currently limited evidence base for best practice in interventions for individuals with psychosis who choose not to take antipsychotics.

Suggested Citation

  • Anthony Morrison & Melissa Wardle & Paul Hutton & Linda Davies & Graham Dunn & Alison Brabban & Rory Byrne & Laura Drage & Helen Spencer & Douglas Turkington, 2013. "Assessing Cognitive Therapy Instead Of Neuroleptics: Rationale, study design and sample characteristics of the ACTION trial," Psychosis, Taylor & Francis Journals, vol. 5(1), pages 82-92.
    • Handle: RePEc:taf:rpsyxx:v:5:y:2013:i:1:p:82-92
    DOI: 10.1080/17522439.2012.756539
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