IDEAS home Printed from https://ideas.repec.org/a/taf/mpopst/v18y2011i2p106-121.html
   My bibliography  Save this article

Emergence of Resistance in Influenza With Compensatory Mutations

Author

Listed:
  • SEYED MOGHADAS

Abstract

Compensatory mutations are evolutionary responses of influenza viruses resulting in the generation of escape mutants from immune recognition or in the emergence of highly transmissible drug resistant viruses. Model simulations show that: (i) resistance is unlikely to develop without compensation for the large fitness cost associated with the initial rise of resistant mutants; and (ii) in the absence of virus-specific immune memory, the beginning of the treatment and the efficacy of drugs in suppressing viral replication are critical measures in the invasion of compensated mutants. However, pre-existing immune responses can prevent the outgrowth of resistance, regardless of treatment regimes. The presence of immune memory may be a key factor in preventing lethal consequences of infection.

Suggested Citation

  • Seyed Moghadas, 2011. "Emergence of Resistance in Influenza With Compensatory Mutations," Mathematical Population Studies, Taylor & Francis Journals, vol. 18(2), pages 106-121.
  • Handle: RePEc:taf:mpopst:v:18:y:2011:i:2:p:106-121
    DOI: 10.1080/08898480.2011.564565
    as

    Download full text from publisher

    File URL: http://www.tandfonline.com/doi/abs/10.1080/08898480.2011.564565
    Download Restriction: Access to full text is restricted to subscribers.

    As the access to this document is restricted, you may want to search for a different version of it.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:taf:mpopst:v:18:y:2011:i:2:p:106-121. See general information about how to correct material in RePEc.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: (Chris Longhurst). General contact details of provider: http://www.tandfonline.com/GMPS20 .

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service hosted by the Research Division of the Federal Reserve Bank of St. Louis . RePEc uses bibliographic data supplied by the respective publishers.