Emergence of Resistance in Influenza With Compensatory Mutations
Compensatory mutations are evolutionary responses of influenza viruses resulting in the generation of escape mutants from immune recognition or in the emergence of highly transmissible drug resistant viruses. Model simulations show that: (i) resistance is unlikely to develop without compensation for the large fitness cost associated with the initial rise of resistant mutants; and (ii) in the absence of virus-specific immune memory, the beginning of the treatment and the efficacy of drugs in suppressing viral replication are critical measures in the invasion of compensated mutants. However, pre-existing immune responses can prevent the outgrowth of resistance, regardless of treatment regimes. The presence of immune memory may be a key factor in preventing lethal consequences of infection.
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Volume (Year): 18 (2011)
Issue (Month): 2 ()
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