IDEAS home Printed from
   My bibliography  Save this article

Biomechanical and Nutrient Controls in the Growth of Mammalian Cell Populations




Growth kinetics and morphologies of growing mammalian cell populations are part of the growth dynamics of tumors. A biophysical agent-based simulation model describes a biological cell by a homogeneous elastic adhesive object able to migrate, grow and divide, and die. A comparison of simulation results with experimental data shows that the growth kinetics of growing multicellular spheroids (MCS) over a wide range of nutrient concentrations is explained by a bio-mechanical form of contact inhibition between cells. This inhibition mechanism explains the growth kinetics of the tumor diameter and the cell population size, the size of the necrotic core, the median cell volume, which decreases when the tumor diameter increases, and the spatial distribution of cell volumes in the tumor. The same model is used to predict how cell populations survive in low nutrient concentrations. Spatial patterns are different for changes of the cell phenotype by regulation or mutation. The cells appearing in the simulations decrease cell-cell adhesion, display chemotaxis movement, increase micro-motility and decrease cell cycle time. Each of these have been observed in invasive cancers.

Suggested Citation

  • Stefan Hoehme & Dirk Drasdo, 2010. "Biomechanical and Nutrient Controls in the Growth of Mammalian Cell Populations," Mathematical Population Studies, Taylor & Francis Journals, vol. 17(3), pages 166-187.
  • Handle: RePEc:taf:mpopst:v:17:y:2010:i:3:p:166-187
    DOI: 10.1080/08898480.2010.491032

    Download full text from publisher

    File URL:
    Download Restriction: Access to full text is restricted to subscribers.

    As the access to this document is restricted, you may want to search for a different version of it.


    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:taf:mpopst:v:17:y:2010:i:3:p:166-187. See general information about how to correct material in RePEc.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: (Chris Longhurst). General contact details of provider: .

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service hosted by the Research Division of the Federal Reserve Bank of St. Louis . RePEc uses bibliographic data supplied by the respective publishers.