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Feedback Spreading Control Applied to Immunotherapy


  • Khalid Kassara


How should immunotherapy be controlled so as to eliminate cancer cells from a tissue? The populations of immune cells, tumor cells, chemokine and complexes are governed by four semilinear partial differential equations controlled by both the dosage of effector cells and the therapy zone. The corresponding control problems are formulated in the framework of feedback spreading control (FSC) seeking to expand the zones without tumor cells to the entire tissue. Algorithms for computing FSC laws are used to demonstrate how the dosage of effector cells and the therapy zones are determined in order to provide feedback therapy protocols which keep the patient healthy.

Suggested Citation

  • Khalid Kassara, 2005. "Feedback Spreading Control Applied to Immunotherapy," Mathematical Population Studies, Taylor & Francis Journals, vol. 12(4), pages 211-221.
  • Handle: RePEc:taf:mpopst:v:12:y:2005:i:4:p:211-221
    DOI: 10.1080/08898480500301819

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