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Joint modeling of multivariate hearing thresholds measured longitudinally at multiple frequencies

Author

Listed:
  • Mulugeta Gebregziabher
  • Mark A. Eckert
  • Lois J. Matthews
  • Abeba A. Teklehaimanot
  • Judy R. Dubno

Abstract

Pure-tone thresholds are used to estimate hearing acuity and, when measured longitudinally, can characterize age-related changes in hearing. Measured at multiple-frequencies, multiple-irregular time points, for right and left ears, these longitudinal studies of age-related hearing loss produce data of inherent complexity due to: 1) multivariate outcomes at different frequencies; 2) longitudinal measurements taken at subject-specific time intervals; and 3) inter-ear correlations due to clustering and nesting. To address limitations in existing methods, we propose a multivariate generalized linear mixed model (mGLMM) and assess its performance. We demonstrate its application using a unique dataset from a cohort study of age-related hearing loss.

Suggested Citation

  • Mulugeta Gebregziabher & Mark A. Eckert & Lois J. Matthews & Abeba A. Teklehaimanot & Judy R. Dubno, 2018. "Joint modeling of multivariate hearing thresholds measured longitudinally at multiple frequencies," Communications in Statistics - Theory and Methods, Taylor & Francis Journals, vol. 47(22), pages 5418-5434, November.
    • Handle: RePEc:taf:lstaxx:v:47:y:2018:i:22:p:5418-5434
    DOI: 10.1080/03610926.2017.1395045
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