IDEAS home Printed from
MyIDEAS: Log in (now much improved!) to save this article

Searching for Alternative Splicing With a Joint Model on Probe Measurability and Expression Intensities

Listed author(s):
  • Jianhua Hu
  • Xuming He
Registered author(s):

    The exon tiling array offers a high throughput technology to search for aberrant splicing in biomedical research, but few methods of analysis for splicing detection have been tested both statistically and empirically. Noisy measurements on nonresponsive probe selection regions and outlying intensities at some of the samples tend to distort model-based assessments. We propose a robust analysis of variance approach that incorporates an informative model on probe measurability and uses median regression rank scores for better reliability in alternative splicing detection. We study the validity and effectiveness of our proposed approach in contrast with some of the existing methods through an empirical investigation of a brain cancer experiment, where a set of biologically validated genes for splicing and nonsplicing are available. Our study demonstrates favorable performance of the proposed ranking method, but shows that analysis of statistical significance cannot be trusted from any conventional use of p -values. We warn of any routine attempt to interpret p -values and their derivatives in model-based detection of alternative splicing.

    If you experience problems downloading a file, check if you have the proper application to view it first. In case of further problems read the IDEAS help page. Note that these files are not on the IDEAS site. Please be patient as the files may be large.

    File URL:
    Download Restriction: Access to full text is restricted to subscribers.

    As the access to this document is restricted, you may want to look for a different version under "Related research" (further below) or search for a different version of it.

    Article provided by Taylor & Francis Journals in its journal Journal of the American Statistical Association.

    Volume (Year): 107 (2012)
    Issue (Month): 499 (September)
    Pages: 935-945

    in new window

    Handle: RePEc:taf:jnlasa:v:107:y:2012:i:499:p:935-945
    DOI: 10.1080/01621459.2012.682801
    Contact details of provider: Web page:

    Order Information: Web:

    No references listed on IDEAS
    You can help add them by filling out this form.

    This item is not listed on Wikipedia, on a reading list or among the top items on IDEAS.

    When requesting a correction, please mention this item's handle: RePEc:taf:jnlasa:v:107:y:2012:i:499:p:935-945. See general information about how to correct material in RePEc.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: (Chris Longhurst)

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If references are entirely missing, you can add them using this form.

    If the full references list an item that is present in RePEc, but the system did not link to it, you can help with this form.

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your profile, as there may be some citations waiting for confirmation.

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    This information is provided to you by IDEAS at the Research Division of the Federal Reserve Bank of St. Louis using RePEc data.