IDEAS home Printed from https://ideas.repec.org/a/taf/japsta/v45y2018i11p2007-2019.html
   My bibliography  Save this article

Discussion on the issue of sample size determination for a targeted to an untargeted and to a mixed effect model-based clinical trial design

Author

Listed:
  • Feng-shou Ko

Abstract

More and more studies have shown that genetic determinants may mediate variability among persons in the response to a drug. In other words, some therapeutics benefit only a subset of treated patients. Genomic technologies – such as DNA sequencing, mRNA transcript profiling, and comparative genomic hybridization – are providing biomarkers that can be used to predict which patients are most likely to respond to a given drug. In this paper, the sample size determination of a targeted clinical trial, an untargeted clinical trial and a random effect model is conducted. Treatment effect for the responder and non-responder patients, the assay specificity and sensitivity, and the proportion of the population for non-responder can affect sample size determination of the experimental design.

Suggested Citation

  • Feng-shou Ko, 2018. "Discussion on the issue of sample size determination for a targeted to an untargeted and to a mixed effect model-based clinical trial design," Journal of Applied Statistics, Taylor & Francis Journals, vol. 45(11), pages 2007-2019, August.
    • Handle: RePEc:taf:japsta:v:45:y:2018:i:11:p:2007-2019
    DOI: 10.1080/02664763.2017.1405915
    as

    Download full text from publisher

    File URL: http://hdl.handle.net/10.1080/02664763.2017.1405915
    Download Restriction: Access to full text is restricted to subscribers.
    File URL: https://libkey.io/10.1080/02664763.2017.1405915?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:taf:japsta:v:45:y:2018:i:11:p:2007-2019. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Chris Longhurst (email available below). General contact details of provider: http://www.tandfonline.com/CJAS20 .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.