IDEAS home Printed from https://ideas.repec.org/a/taf/japsta/v38y2011i7p1493-1498.html
   My bibliography  Save this article

A class of designs for Phase I cancer clinical trials combining Bayesian and likelihood approaches

Author

Listed:
  • Zheng Su

Abstract

The Bayesian continual reassessment method (CRM) and its likelihood version (CRML) provide important tools for the design of Phase I cancer clinical trials. However, a poorly chosen prior distribution in CRM may lead to inferior performance of the method in the early stage of a trial, whereas the maximum-likelihood estimate used in CRML may result in initial high variability. These features of CRM and CRML served as the motivations for the development of this new class of designs, which combines the Bayesian and the likelihood approaches and has CRM and CRML as special cases. Simulation studies on a leukaemia trial show that the proposed class of designs significantly outperforms the traditional up-and-down design.

Suggested Citation

  • Zheng Su, 2011. "A class of designs for Phase I cancer clinical trials combining Bayesian and likelihood approaches," Journal of Applied Statistics, Taylor & Francis Journals, vol. 38(7), pages 1493-1498, June.
    • Handle: RePEc:taf:japsta:v:38:y:2011:i:7:p:1493-1498
    DOI: 10.1080/02664763.2010.505955
    as

    Download full text from publisher

    File URL: http://hdl.handle.net/10.1080/02664763.2010.505955
    Download Restriction: Access to full text is restricted to subscribers.
    File URL: https://libkey.io/10.1080/02664763.2010.505955?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:taf:japsta:v:38:y:2011:i:7:p:1493-1498. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Chris Longhurst (email available below). General contact details of provider: http://www.tandfonline.com/CJAS20 .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.