IDEAS home Printed from https://ideas.repec.org/a/taf/gcmbxx/v15y2012i6p571-583.html
   My bibliography  Save this article

A mathematical model of medial collateral ligament repair: migration, fibroblast proliferation and collagen formation

Author

Listed:
  • D. Garzón-Alvarado
  • R. Cárdenas Sandoval
  • J. Vanegas Acosta

Abstract

The partial rupture of ligament fibres leads to an injury known as grade 2 sprain. Wound healing after injury consists of four general stages: swelling, release of platelet-derived growth factor (PDGF), fibroblast migration and proliferation and collagen production. The aim of this paper is to present a mathematical model based on reaction–diffusion equations for describing the repair of the medial collateral ligament when it has suffered a grade 2 sprain. We have used the finite element method to solve the equations of this. The results have simulated the tissue swelling at the time of injury, predicted PDGF influence, the concentration of fibroblasts migrating towards the place of injury and reproduced the random orientation of immature collagen fibres. These results agree with experimental data reported by other authors. The model describes wound healing during the 9 days following such injury.

Suggested Citation

  • D. Garzón-Alvarado & R. Cárdenas Sandoval & J. Vanegas Acosta, 2012. "A mathematical model of medial collateral ligament repair: migration, fibroblast proliferation and collagen formation," Computer Methods in Biomechanics and Biomedical Engineering, Taylor & Francis Journals, vol. 15(6), pages 571-583.
    • Handle: RePEc:taf:gcmbxx:v:15:y:2012:i:6:p:571-583
    DOI: 10.1080/10255842.2010.550887
    as

    Download full text from publisher

    File URL: http://hdl.handle.net/10.1080/10255842.2010.550887
    Download Restriction: Access to full text is restricted to subscribers.
    File URL: https://libkey.io/10.1080/10255842.2010.550887?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:taf:gcmbxx:v:15:y:2012:i:6:p:571-583. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Chris Longhurst (email available below). General contact details of provider: http://www.tandfonline.com/gcmb .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.