IDEAS home Printed from https://ideas.repec.org/a/taf/gcmbxx/v15y2012i3p231-248.html
   My bibliography  Save this article

Biomechanical response of ascending thoracic aortic aneurysms: association with structural remodelling

Author

Listed:
  • Dimitrios Sokolis
  • Eleftherios Kritharis
  • Athina Giagini
  • Konstantinos Lampropoulos
  • Stavroula Papadodima
  • Dimitrios Iliopoulos

Abstract

Ascending thoracic aortic aneurysms (ATAA) were resected from patients during graft replacement and non-aneurysmal vessels during autopsy. Tissues were histomechanically tested according to region and orientation, and the experimental recordings reduced with a Fung-type strain–energy function, affording faithful biomechanical characterisation of the vessel response. The material and rupture properties disclosed that ATAA and non-aneurysmal aorta were stiffer and stronger circumferentially, accounted by preferential collagen reinforcement. The deviation of microstructure in the right lateral region, with a longitudinal extracellular matrix and smooth muscle element sub-intimally, reflects the regional differences in material properties identified. ATAA had no effect on strength, but caused stiffening and extensibility reduction, corroborating our histological observation of deficient elastin but not collagen content. Our findings may serve as input data for the implementation of finite element models, to be used as improved surgical intervention criteria, and may further our understanding of the pathophysiology of ATAA and aortic dissection.

Suggested Citation

  • Dimitrios Sokolis & Eleftherios Kritharis & Athina Giagini & Konstantinos Lampropoulos & Stavroula Papadodima & Dimitrios Iliopoulos, 2012. "Biomechanical response of ascending thoracic aortic aneurysms: association with structural remodelling," Computer Methods in Biomechanics and Biomedical Engineering, Taylor & Francis Journals, vol. 15(3), pages 231-248.
    • Handle: RePEc:taf:gcmbxx:v:15:y:2012:i:3:p:231-248
    DOI: 10.1080/10255842.2010.522186
    as

    Download full text from publisher

    File URL: http://hdl.handle.net/10.1080/10255842.2010.522186
    Download Restriction: Access to full text is restricted to subscribers.
    File URL: https://libkey.io/10.1080/10255842.2010.522186?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:taf:gcmbxx:v:15:y:2012:i:3:p:231-248. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Chris Longhurst (email available below). General contact details of provider: http://www.tandfonline.com/gcmb .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.