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Quantifying the mechanical properties of human skin to optimise future microneedle device design

Author

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  • R. Groves
  • S. Coulman
  • J. Birchall
  • S. Evans

Abstract

Microneedle devices are a promising minimally invasive means of delivering drugs/vaccines across or into the skin. However, there is currently a diversity of microneedle designs and application methods that have, primarily, been intuitively developed by the research community. To enable the rational design of optimised microneedle devices, a greater understanding of human skin biomechanics under small deformations is required. This study aims to develop a representative stratified model of human skin, informed by in vivo data. A multilayer finite element model incorporating the epidermis, dermis and hypodermis was established. This was correlated with a series of in-vivo indentation measurements, and the Ogden material coefficients were optimised using a material parameter extraction algorithm. The finite element simulation was subsequently used to model microneedle application to human skin before penetration and was validated by comparing these predictions with the in-vivo measurements. Our model has provided an excellent tool to predict micron-scale human skin deformation in vivo and is currently being used to inform optimised microneedle designs.

Suggested Citation

  • R. Groves & S. Coulman & J. Birchall & S. Evans, 2012. "Quantifying the mechanical properties of human skin to optimise future microneedle device design," Computer Methods in Biomechanics and Biomedical Engineering, Taylor & Francis Journals, vol. 15(1), pages 73-82.
    • Handle: RePEc:taf:gcmbxx:v:15:y:2012:i:1:p:73-82
    DOI: 10.1080/10255842.2011.596481
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    Cited by:

    1. Huixiang Huang & Wencheng Tang & Bin Yan & Bin Wu & Dan Cao, 2016. "Mechanical responses of the periodontal ligament based on an exponential hyperelastic model: a combined experimental and finite element method," Computer Methods in Biomechanics and Biomedical Engineering, Taylor & Francis Journals, vol. 19(2), pages 188-198, January.

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