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Finite element study of a tissue-engineered cartilage transplant in human tibiofemoral joint

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  • Ali Vahdati
  • Diane Wagner

Abstract

Most tissue-engineered cartilage constructs are more compliant than native articular cartilage (AC) and are poorly integrated to the surrounding tissue. To investigate the effect of an implanted tissue-engineered construct (TEC) with these inferior properties on the mechanical environment of both the engineered and adjacent native tissues, a finite element study was conducted. Biphasic swelling was used to model tibial cartilage and an implanted TEC with the material properties of either native tissue or a decreased elastic modulus and fixed charged density. Creep loading was applied with a rigid impermeable indenter that represented the femur. In comparison with an intact joint, compressive strains in the transplant, surface contact stress in the adjacent native AC and load partitioning between different phases of cartilage were affected by inferior properties of TEC. Results of this study may lead to a better understanding of the complex mechanical environment of an implanted TEC.

Suggested Citation

  • Ali Vahdati & Diane Wagner, 2012. "Finite element study of a tissue-engineered cartilage transplant in human tibiofemoral joint," Computer Methods in Biomechanics and Biomedical Engineering, Taylor & Francis Journals, vol. 15(11), pages 1211-1221.
    • Handle: RePEc:taf:gcmbxx:v:15:y:2012:i:11:p:1211-1221
    DOI: 10.1080/10255842.2011.585974
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    References listed on IDEAS

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    1. Kathryn E. Keenan & Lampros C. Kourtis & Thor F. Besier & Derek P. Lindsey & Garry E. Gold & Scott L. Delp & Gary S. Beaupre, 2009. "New resource for the computation of cartilage biphasic material properties with the interpolant response surface method," Computer Methods in Biomechanics and Biomedical Engineering, Taylor & Francis Journals, vol. 12(4), pages 415-422.
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    Cited by:

    1. C. Bandeiras & A. Completo, 2013. "Comparison between constitutive models for the solid phase of biphasic agarose/chondrocytes constructs for knee cartilage engineering," Computer Methods in Biomechanics and Biomedical Engineering, Taylor & Francis Journals, vol. 16(S1), pages 262-263, July.
    2. Jérôme Hollenstein & Alexandre Terrier & Esther Cory & Albert C. Chen & Robert L. Sah & Dominique P. Pioletti, 2015. "Mechanical evaluation of a tissue-engineered zone of calcification in a bone–hydrogel osteochondral construct," Computer Methods in Biomechanics and Biomedical Engineering, Taylor & Francis Journals, vol. 18(3), pages 332-337, February.

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