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Economic Evaluations of Pharmacological Treatments in Heart Failure Patients: A Methodological Review with a Focus on Key Model Drivers


  • Gian Luca Di Tanna

    (The George Institute for Global Health)

  • Shuxian Chen

    (University of Washington)

  • Anna Bychenkova

    (Amgen Inc.)

  • Heidi S. Wirtz

    (Amgen Inc.)

  • Karen L. Burrows

    (Envision Pharma Group)

  • Gary Globe

    (Amgen Inc.)


Various decision analytic models exist for evaluating the cost-effectiveness of pharmacological interventions for heart failure (HF). Despite this, studies that explore drivers influencing these modeling approaches remain scarce. Through a systematic review of the literature, the present study sought to identify model drivers that emerge from economic evaluations of HF pharmacological interventions. Among the 72 cost effectiveness papers evaluating HF drug interventions, the most frequently identified, top 5 ranked model drivers impacting the incremental cost-effectiveness ratio (ICER) were cost of treatment and utility, identified in 10% of studies, respectively. Other drivers that emerged as top 5 ranked drivers in > 5% of studies included treatment effect on mortality (or cardiovascular mortality), duration of treatment, and baseline cardiovascular mortality. Model drivers reported at the top of tornado diagrams were treatment effect on mortality or on cardiovascular mortality. Collectively, these observations highlight the key importance of treatment effect in driving cost-effectiveness models for HF.

Suggested Citation

  • Gian Luca Di Tanna & Shuxian Chen & Anna Bychenkova & Heidi S. Wirtz & Karen L. Burrows & Gary Globe, 2020. "Economic Evaluations of Pharmacological Treatments in Heart Failure Patients: A Methodological Review with a Focus on Key Model Drivers," PharmacoEconomics - Open, Springer, vol. 4(3), pages 397-401, September.
  • Handle: RePEc:spr:pharmo:v:4:y:2020:i:3:d:10.1007_s41669-019-00173-y
    DOI: 10.1007/s41669-019-00173-y

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    Blog mentions

    As found by, the blog aggregator for Economics research:
    1. Rita Faria’s journal round-up for 14th September 2020
      by Rita Faria in The Academic Health Economists' Blog on 2020-09-14 11:00:07


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    Cited by:

    1. Clare Proudfoot & Raju Gautam & Joaquim Cristino & Rumjhum Agrawal & Lalit Thakur & Keith Tolley, 2023. "Model parameters influencing the cost-effectiveness of sacubitril/valsartan in heart failure: evidence from a systematic literature review," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 24(3), pages 453-467, April.
    2. Gian Luca Di Tanna & Blake Angell & Michael Urbich & Peter Lindgren & Thomas A. Gaziano & Gary Globe & Björn Stollenwerk, 2022. "A Proposal of a Cost-Effectiveness Modeling Approach for Heart Failure Treatment Assessment: Considering the Short- and Long-Term Impact of Hospitalization on Event Rates," PharmacoEconomics, Springer, vol. 40(11), pages 1095-1105, November.

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