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Heterogeneity in Economic Value of SGLT2is for Type 2 Diabetes: Subgroup Modeling Cost-Effectiveness Analyses

Author

Listed:
  • Kah Suan Chong

    (National Cheng Kung University)

  • Chun-Ting Yang

    (National Cheng Kung University
    Brigham and Women’s Hospital, Harvard Medical School)

  • Chi-Chuan Wang

    (National Taiwan University
    National Taiwan University
    National Taiwan University Hospital)

  • Huang-Tz Ou

    (National Cheng Kung University
    National Cheng Kung University)

  • Shihchen Kuo

    (National Cheng Kung University
    University of Michigan Medical School)

Abstract

Background and Objective Although heterogeneous treatment effects of sodium-glucose cotransporter 2 inhibitors (SGLT2is) have been revealed, the heterogeneous economic value of SGLT2is in real-world type 2 diabetes (T2D) populations with diverse clinical characteristics remains unclear. We conducted subgroup cost-effectiveness analyses of SGLT2is versus dipeptidyl peptidase 4 inhibitors (DPP4is) among patients with T2D. Methods A multi-state transition model was used to estimate the incremental cost-effectiveness ratios (ICERs, in US$ per quality-adjusted life-years [QALYs] gained) and value-based pricing (VBP) among patients with T2D stratified by age, estimated glomerular filtration rate (eGFR), glycated hemoglobin (HbA1c), and body mass index (BMI) over 5 years and a Lifetime horizon from a healthcare sector perspective, with both costs and quality-adjusted Life years discounted at 3% annually. Model inputs included treatment effects derived from analysis of individual-level data in Taiwan, and health utilities and costs sourced from published Literature of Taiwanese populations. Deterministic and probabilistic sensitivity analyses across subgroups were performed. All costs were standardized to 2022. Results Over 5 years, the ICERs of SGLT2is versus DPP4is were as follows: age subgroups (

Suggested Citation

  • Kah Suan Chong & Chun-Ting Yang & Chi-Chuan Wang & Huang-Tz Ou & Shihchen Kuo, 2025. "Heterogeneity in Economic Value of SGLT2is for Type 2 Diabetes: Subgroup Modeling Cost-Effectiveness Analyses," PharmacoEconomics, Springer, vol. 43(12), pages 1451-1461, December.
    • Handle: RePEc:spr:pharme:v:43:y:2025:i:12:d:10.1007_s40273-025-01536-6
    DOI: 10.1007/s40273-025-01536-6
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