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Incorporating Pharmacometrics into Pharmacoeconomic Models: Applications from Drug Development


  • Meenakshi Srinivasan

    (University of North Texas System College of Pharmacy)

  • Annesha White

    (University of North Texas System College of Pharmacy)

  • Ayyappa Chaturvedula

    (University of North Texas System College of Pharmacy)

  • Valvanera Vozmediano

    (University of Florida)

  • Stephan Schmidt

    (University of Florida)

  • Leo Plouffe

    (Bayer HealthCare)

  • La’Marcus T. Wingate

    (Howard University)


Pharmacometrics is the science of quantifying the relationship between the pharmacokinetics and pharmacodynamics of drugs in combination with disease models and trial information to aid in drug development and dosing optimization for clinical practice. Considering the variability in the dose–concentration–effect relationship of drugs, an opportunity exists in linking pharmacokinetic and pharmacodynamic model-based estimates with pharmacoeconomic models. This link may provide early estimates of the cost effectiveness of drug therapies, thus informing late-stage drug development, pricing, and reimbursement decisions. Published case studies have demonstrated how integrated pharmacokinetic–pharmacodynamic–pharmacoeconomic models can complement traditional pharmacoeconomic analyses by identifying the impact of specific patient sub-groups, dose, dosing schedules, and adherence on the cost effectiveness of drugs, thus providing a mechanistic basis to predict the economic value of new drugs. Greater collaboration between the pharmacoeconomics and pharmacometrics community can enable methodological improvements in pharmacokinetic–pharmacodynamic–pharmacoeconomic models to support drug development.

Suggested Citation

  • Meenakshi Srinivasan & Annesha White & Ayyappa Chaturvedula & Valvanera Vozmediano & Stephan Schmidt & Leo Plouffe & La’Marcus T. Wingate, 2020. "Incorporating Pharmacometrics into Pharmacoeconomic Models: Applications from Drug Development," PharmacoEconomics, Springer, vol. 38(10), pages 1031-1042, October.
  • Handle: RePEc:spr:pharme:v:38:y:2020:i:10:d:10.1007_s40273-020-00944-0
    DOI: 10.1007/s40273-020-00944-0

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    Blog mentions

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    1. Chris Sampson’s journal round-up for 12th October 2020
      by Chris Sampson in The Academic Health Economists' Blog on 2020-10-12 11:00:03

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