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Economic Burden of Renal Cell Carcinoma—Part I: An Updated Review

Author

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  • Chun-Ru Chien

    (China Medical University Hospital
    China Medical University)

  • Daniel M. Geynisman

    (Fox Chase Cancer Center, Temple Health)

  • Bumyang Kim

    (University of Texas MD Anderson Cancer Center)

  • Ying Xu

    (University of Texas MD Anderson Cancer Center)

  • Ya-Chen Tina Shih

    (University of Texas MD Anderson Cancer Center)

Abstract

Background The economic burden of renal cell carcinoma (RCC) had been reported to be significant in a previous review published in 2011. Objective The objective of this study was to perform an updated review by synthesizing economic studies related to the treatment of RCC that have been published since the previous review. Methods We performed a literature search in PubMed, EMBASE, and the Cochrane Library, covering English-language studies published between June 2010 and August 2018. We categorized these articles by type of analyses [cost-effectiveness analysis (CEA), cost analysis, and cost of illness (COI)] and treatment setting (cancer status and treatment), discussed findings from these articles, and synthesized information from each article in summary tables. Results We identified 52 studies from 2317 abstracts/titles deemed relevant from the initial search, including 21 CEA, 23 cost analysis, and 8 COI studies. For localized RCC, costs were found to be positively associated with the aggressiveness of the local treatment. For metastatic RCC (mRCC), pazopanib was reported to be cost effective in the first-line setting. We also found that the economic burden of RCC has increased over time. Conclusion RCC continues to impose a substantial economic burden to the healthcare system. Despite the large number of treatment alternatives now available for advanced RCC, the cost effectiveness and budgetary impact of many new agents remain unknown and warrant greater attention in future research.

Suggested Citation

  • Chun-Ru Chien & Daniel M. Geynisman & Bumyang Kim & Ying Xu & Ya-Chen Tina Shih, 2019. "Economic Burden of Renal Cell Carcinoma—Part I: An Updated Review," PharmacoEconomics, Springer, vol. 37(3), pages 301-331, March.
    • Handle: RePEc:spr:pharme:v:37:y:2019:i:3:d:10.1007_s40273-018-0746-y
    DOI: 10.1007/s40273-018-0746-y
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    Cited by:

    1. Chia-Chin Li & Ying-Chun Lin & Ji-An Liang & K. S. Clifford Chao & Te-Chun Hsia & Chun-Ru Chien, 2023. "Health Economic Evaluation of Proton Therapy for Lung Cancer: A Systematic Review," IJERPH, MDPI, vol. 20(6), pages 1-10, March.

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