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Chronic hepatitis C virus infection in the Czech Republic and Slovakia: an analysis of patient and virus characteristics

Author

Listed:
  • Lubomír Skladaný

    (FD Roosevelt University Hospital of Slovak Medical University, HEGITO (Division Hepatology, Gastroenterology and Liver Transplantation))

  • Marian Oltman

    (Center for Gastroenterology and Hepatology Thalion)

  • Soňa Fraňková

    (Institute for Clinical and Experimental Medicine)

  • Sylvia Dražilová

    (Hospital Poprad
    P.J. Safarik University and L. Pasteur University Hospital)

  • Petr Husa

    (Masaryk University)

  • Jan Šperl

    (Institute for Clinical and Experimental Medicine)

  • Václav Hejda

    (Charles University Medical School and Teaching Hospital)

  • Petr Urbánek

    (Charles University and Central Military Hospital)

  • Svetlana Adamcová-Selčanová

    (FD Roosevelt University Hospital of Slovak Medical University, HEGITO (Division Hepatology, Gastroenterology and Liver Transplantation))

  • Martin Janičko

    (P.J. Safarik University and L. Pasteur University Hospital)

  • Pavol Kristian

    (P.J. Safarik University and L. Pasteur University Hospital)

  • Viera Kupčová

    (Derer’s Hospital)

  • Marek Rác

    (Teaching Hospital)

  • Ivan Schréter

    (P.J. Safarik University and L. Pasteur University Hospital)

  • Ladislav Virág

    (P.J. Safarik University and L. Pasteur University Hospital)

  • Adriana Liptáková

    (Commenius University)

  • Miriam Ondrášová

    (Abbvie Slovakia and PhD. Studies at Saint Elisabeth University of Health and Social Sciences)

  • Peter Jarčuška

    (P.J. Safarik University and L. Pasteur University Hospital)

Abstract

Objectives The MOSAIC study gathered data on chronic hepatitis C virus (HCV) infection and its treatment in various countries worldwide. Here we summarise patient and HCV characteristics in the Czech Republic and Slovakia. Methods MOSAIC was an observational study that included patients with chronic HCV infection untreated at the time of enrolment. Study collected and descriptively analysed patient demographics, disease stage and viral characteristics. Data were collected between February 2014 to October 2014. Results Among 220 patients enrolled, 51.4% were treatment-naïve. The most prevalent HCV genotype was G1 (78.4%), followed by G3 (19.7%). Higher prevalence of G1 was found in treatment-experienced patients (94.3%) compared to treatment-naïve (63.4%). Most participants (67.7%) presented viral RNA load of ≥ 800,000 IU/mL. Liver cirrhosis was reported in 24.5% of patients. Higher HCV RNA load and duration of HCV infection correlated with the degree of liver fibrosis. Anti-HCV interferon-based treatments were initiated in 88.2% of participants. Conclusions The study confirmed significant changes in the HCV genotypes partition with G3 genotype rapidly increasing in both countries, with possible impact on the WHO eradication initiative and treatment selection.

Suggested Citation

  • Lubomír Skladaný & Marian Oltman & Soňa Fraňková & Sylvia Dražilová & Petr Husa & Jan Šperl & Václav Hejda & Petr Urbánek & Svetlana Adamcová-Selčanová & Martin Janičko & Pavol Kristian & Viera Kupčov, 2020. "Chronic hepatitis C virus infection in the Czech Republic and Slovakia: an analysis of patient and virus characteristics," International Journal of Public Health, Springer;Swiss School of Public Health (SSPH+), vol. 65(9), pages 1723-1735, December.
    • Handle: RePEc:spr:ijphth:v:65:y:2020:i:9:d:10.1007_s00038-020-01496-y
    DOI: 10.1007/s00038-020-01496-y
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