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DNA unzipping transition

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  • Somendra M. Bhattacharjee

    (Ashoka University)

Abstract

This review focuses on the force-induced unzipping transition of double-stranded DNA. It begins with a brief history of DNA melting, which emerged alongside the growth of the field of molecular biology, juxtaposed with the advancements in physics during the same post-World War II period. The earlier theories of melting of DNA were based on the Ising model and its modifications, but gradually moved toward polymer-based models. The idea of force-induced unzipping was first introduced in 1999 as a cooperative mechanism for breaking base pairs without the need for temperature changes. The paper discusses several subsequent developments addressing different aspects of the unzipping transition. Graphical abstract

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  • Somendra M. Bhattacharjee, 2025. "DNA unzipping transition," The European Physical Journal B: Condensed Matter and Complex Systems, Springer;EDP Sciences, vol. 98(9), pages 1-20, September.
    • Handle: RePEc:spr:eurphb:v:98:y:2025:i:9:d:10.1140_epjb_s10051-025-01028-8
    DOI: 10.1140/epjb/s10051-025-01028-8
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