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Dissortativity and duplications in oral cancer

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  • Pramod Shinde
  • Alok Yadav
  • Aparna Rai
  • Sarika Jalan

Abstract

More than 300 000 new cases worldwide are being diagnosed with oral cancer annually. Complexity of oral cancer renders designing drug targets very difficult. We analyse protein-protein interaction network for the normal and oral cancer tissue and detect crucial changes in the structural properties of the networks in terms of the interactions of the hub proteins and the degree-degree correlations. Further analysis of the spectra of both the networks, while exhibiting universal statistical behaviour, manifest distinction in terms of the zero degeneracy, providing insight to the complexity of the underlying system. Copyright EDP Sciences, SIF, Springer-Verlag Berlin Heidelberg 2015

Suggested Citation

  • Pramod Shinde & Alok Yadav & Aparna Rai & Sarika Jalan, 2015. "Dissortativity and duplications in oral cancer," The European Physical Journal B: Condensed Matter and Complex Systems, Springer;EDP Sciences, vol. 88(8), pages 1-7, August.
    • Handle: RePEc:spr:eurphb:v:88:y:2015:i:8:p:1-7:10.1140/epjb/e2015-60426-5
    DOI: 10.1140/epjb/e2015-60426-5
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    Statistical and Nonlinear Physics;

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