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On the aging dynamics in an immune network model

Author

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  • M. Copelli
  • R. Zorzenon dos Santos
  • D. Stariolo

Abstract

Recently we have used a cellular automata model which describes the dynamics of a multi-connected network to reproduce the refractory behavior and aging effects obtained in immunization experiments performed with mice when subjected to multiple perturbations. In this paper we investigate the similarities between the aging dynamics observed in this multi-connected network and the one observed in glassy systems, by using the usual tools applied to analyze the latter. An interesting feature we show here, is that the model reproduces the biological aspects observed in the experiments during the long transient time it takes to reach the stationary state. Depending on the initial conditions, and without any perturbation, the system may reach one of a family of long-period attractors. The perturbations may drive the system from its natural attractor to other attractors of the same family. We discuss the different roles played by the small random perturbations ("noise") and by the large periodic perturbations ("immunizations"). Copyright Springer-Verlag Berlin/Heidelberg 2003

Suggested Citation

  • M. Copelli & R. Zorzenon dos Santos & D. Stariolo, 2003. "On the aging dynamics in an immune network model," The European Physical Journal B: Condensed Matter and Complex Systems, Springer;EDP Sciences, vol. 34(1), pages 119-129, July.
  • Handle: RePEc:spr:eurphb:v:34:y:2003:i:1:p:119-129
    DOI: 10.1140/epjb/e2003-00203-7
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