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The metabolic pathway of 4 Hz mechanical vibration-induced effect on snail heart muscle contractility

Author

Listed:
  • Erna Dadasyan

    (UNESCO Chair-Life Science International Postgraduate Educational Center)

  • Gayane Ayrapetyan

    (UNESCO Chair-Life Science International Postgraduate Educational Center)

  • Naira Baghdasaryan

    (UNESCO Chair-Life Science International Postgraduate Educational Center)

  • Yerazik Mikayelyan

    (UNESCO Chair-Life Science International Postgraduate Educational Center)

  • Sinerik Ayrapetyan

    (UNESCO Chair-Life Science International Postgraduate Educational Center)

Abstract

It was shown that the 4 Hz 30 dB mechanical vibration (MV) of physiological solution (PS) had modulation effect on snail heart contractility. However, the nature of metabolic pathway of MV-treated PS-induced effect is not clear yet. It was suggested that the MV-induced modulation of water molecules dissociation leads to the variation of reactive oxygen species’ level in cell bathing medium, which could serve as a messenger for switching on the metabolic pathway(s) responsible for modulation of muscle contractility. The aim of present work was to check this hypothesis and to elucidate the metabolic pathway through which the effect of MV-treated PS on heart contractility was realized. For this purpose, the effect of MV on heat fusion periods (HFP) and H2O2 content in PS, as well as on heart contractility, 45Ca2+ efflux, intracellular levels of cGMP and cAMP, muscle hydration, and ouabain binding were studied. It was shown that MV treatment of PS increased the HFP-(21.33 ± 4%) and decreased the H2O2 content-(5 ± 0.9%). The intracardiac perfusion by MV-treated PS increased the amplitudes of heart contractility, which was accompanied by the increasing of 45Ca2+ efflux (252.4 ± 16%), elevation of cGMP’s level (42.05 ± 7%), decreasing of cAMP’s level (82.67 ± 7%), increasing of the tissue hydration (18.64 ± 3%), and increasing of the number of ouabain binding sides (25 ± 4%). It was suggested that MV-induced increasing of heart muscle contraction amplitudes is due to the decreases of H2O2 content in the medium, which leads to the elevation of heart muscle contractility in result of activation of cGMP-dependent Na+/Ca2+ exchange in forward regime.

Suggested Citation

  • Erna Dadasyan & Gayane Ayrapetyan & Naira Baghdasaryan & Yerazik Mikayelyan & Sinerik Ayrapetyan, 2012. "The metabolic pathway of 4 Hz mechanical vibration-induced effect on snail heart muscle contractility," Environment Systems and Decisions, Springer, vol. 32(2), pages 166-174, June.
    • Handle: RePEc:spr:envsyd:v:32:y:2012:i:2:d:10.1007_s10669-011-9382-1
    DOI: 10.1007/s10669-011-9382-1
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    References listed on IDEAS

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    1. Gayane Ayrapetyan & Anahit Grigoryan & Erna Dadasyan & Sinerik Ayrapetyan, 2007. "The comparative study of the effects of 4 Hz Electromagnetic Fields-, Infrasound-treated and hydrogen peroxide containing physiological solutions on Na pump-induced inhibition of heart muscle contract," Environment Systems and Decisions, Springer, vol. 27(4), pages 483-488, December.
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