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Magnetically treated water at 4 Hz and 2.5 mT as a modulator of cisplatin effect on cell hydration and ouabain binding of sarcoma-180 tissue

Author

Listed:
  • L. R. Yeganyan

    (Life Sciences International Postgraduate Educational Center)

  • R. E. Muradyan

    (NAS RA the Scientific Technological Center of Organic and Pharmaceutical Chemistry SNPO)

  • F. H. Arsenyan

    (NAS RA the Scientific Technological Center of Organic and Pharmaceutical Chemistry SNPO)

  • G. K. Bazikyan

    (National Center of Oncology)

  • S. N. Ayrapetyan

    (Life Sciences International Postgraduate Educational Center)

Abstract

There are many data about the extremely low-frequency electromagnetic fields (ELF-EMF) therapeutic use, especially in the field of oncology. Recent data suggest that 4 Hz EMF having dehydration effect on tissues has a pronounced antitumor activity on sarcoma-180 in mice. It was shown that 4 Hz EMF have pronounced effects on physicochemical properties of water and water solution. Therefore, the aim of the present work was the comparative study of the modulation effect of ELF-EMF on cisplatin-induced changes cell hydration and number of ouabain receptors in membrane of sarcoma-180 tumor tissues. Tissue hydration was measured as wet weight/dry weight and expressed as a water content of g/g in dry weight. The number of 3H-ouabain receptors in membrane was counted by isotope scintillation counter. In conclusion, ELF-EMF can be a possible tool for stimulation of cisPt antitumor effect.

Suggested Citation

  • L. R. Yeganyan & R. E. Muradyan & F. H. Arsenyan & G. K. Bazikyan & S. N. Ayrapetyan, 2012. "Magnetically treated water at 4 Hz and 2.5 mT as a modulator of cisplatin effect on cell hydration and ouabain binding of sarcoma-180 tissue," Environment Systems and Decisions, Springer, vol. 32(2), pages 236-241, June.
  • Handle: RePEc:spr:envsyd:v:32:y:2012:i:2:d:10.1007_s10669-011-9378-x
    DOI: 10.1007/s10669-011-9378-x
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