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Biological activities of the essential oil from the leaves of Lantana montevidensis (Spreng) Briq. in mice

Author

Listed:
  • Maria Rayane Correia Oliveira

    (Regional University of Cariri-URCA, Brazil)

  • Maria Gabriely Lima Silva

    (Regional University of Cariri-URCA, Brazil)

  • Isabel Sousa Alcântara

    (Regional University of Cariri-URCA, Brazil)

  • Jaime Ribeiro Filho

    (Regional University of Cariri-URCA, Brazil)

  • Cícera Datiane de Morais Oliveira Tintino

    (Federal University of Pernambuco-UFPE)

  • Francisco Ernani Alves Magalhães

    (State University of Ceará, Center of Education, Sciences and Technology of the Inhamuns Region-CECITEC)

  • Anita Oliveira Brito Pereira Bezerra Martins

    (Regional University of Cariri-URCA, Brazil)

  • Renata Torres Pessoa

    (Regional University of Cariri-URCA, Brazil)

  • Antonia Eliene Duarte

    (Center for Biological and Health Sciences-CCBS)

  • José Galberto Martins Costa

    (Regional University of Cariri-URCA, Brazil)

  • Sidney Gonçalo Lima

    (Federal University of Piauí-UFPI, Brazil)

  • Henrique Douglas Melo Coutinho

    (Regional University of Cariri-URCA, Brazil)

  • Raffaele Capasso

    (University of Naples Federico II)

  • Irwin Rose Alencar Menezes

    (Regional University of Cariri-URCA, Brazil)

Abstract

This work aimed to analyze the chemical composition and evaluate the anti-inflammatory and antinociceptive properties of the essential oil obtained from the leaves of Lantana montevidensis (OEFLM) in mice. The chemical composition of the OEFLM was analyzed by GC–MS, and its effects on the central nervous system were determined by the open field and rotarod tests. The antinociceptive and anti-inflammatory screenings were conducted using the formalin test, as well as the acetic acid-induced abdominal contortion assay. The antinociceptive activity was assessed by the tail-flick and hot plate tests. The systemic anti-inflammatory activity was determined using models of paw edema induced by carrageenan, dextran, histamine, or arachidonic acid. The effects of the essential oil on vascular permeability and granuloma formation were also investigated. The chemical composition of the OEFLM revealed the presence of valencene (17.93%), bicyclogermacrene (16.35%), trans-caryophyllene (12.84%) and germacrene D (12.18%). The administration of OEFLM at the dose of 2000 mg/Kg caused no evident toxicity. While OEFLM (25, 50, 100, and 200 mg/kg) did not present significant anxiolytic-loke or sedative effects, it showed promising antinociceptive and anti-inflammatory activities. The results of this study indicate that the OEFLM has analgesic and anti-inflammatory activities in animal models by inhibiting acute and chronic inflammation.

Suggested Citation

  • Maria Rayane Correia Oliveira & Maria Gabriely Lima Silva & Isabel Sousa Alcântara & Jaime Ribeiro Filho & Cícera Datiane de Morais Oliveira Tintino & Francisco Ernani Alves Magalhães & Anita Oliveira, 2021. "Biological activities of the essential oil from the leaves of Lantana montevidensis (Spreng) Briq. in mice," Environment, Development and Sustainability: A Multidisciplinary Approach to the Theory and Practice of Sustainable Development, Springer, vol. 23(10), pages 14958-14981, October.
    • Handle: RePEc:spr:endesu:v:23:y:2021:i:10:d:10.1007_s10668-021-01281-8
    DOI: 10.1007/s10668-021-01281-8
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