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Risk of Systemic Inflammatory Response Syndrome Following Preoperative Glucocorticoids Administration in Patients After Percutaneous Nephrolithotomy: A Retrospective Cohort Study

Author

Listed:
  • Jingping Hu

    (The Third Affiliated Hospital of Sun Yat-sen University)

  • Chaojin Chen

    (The Third Affiliated Hospital of Sun Yat-sen University)

  • Xiaoyue Li

    (The Third Affiliated Hospital of Sun Yat-sen University)

  • Xiangyang Zang

    (The Third Affiliated Hospital of Sun Yat-sen University)

  • Jie Ke

    (Guangzhou AID Cloud Technology Co., Ltd)

  • Shaoli Zhou

    (The Third Affiliated Hospital of Sun Yat-sen University)

  • Haiyan Mai

    (The Third Affiliated Hospital of Sun Yat-sen University)

  • Chulian Gong

    (The Third Affiliated Hospital of Sun Yat-sen University)

Abstract

Introduction Systemic inflammatory response syndrome (SIRS) is one of the most serious complications in patients undergoing percutaneous nephrolithotomy (PCNL). Although glucocorticoids are increasingly used during PCNL, few studies have been concerned about the association between glucocorticoids and postoperative SIRS. The study aims to explore whether preoperative use of glucocorticoids is associated with SIRS after PCNL. Methods A total of 1259 patients who underwent PCNL between January 2015 and April 2021 were enrolled in the retrospective cohort study. Risk factors for post-PCNL SIRS were identified by univariate and multivariate regression analysis. To further explore the association between preoperative administration of glucocorticoids and SIRS, 113 pairs of patients were matched for the confounding factors using propensity score matching (PSM) analysis. The odds ratios (OR) and 95 % confidence intervals (CI) for the above variables were analyzed. Results The incidence of SIRS after PCNL was 9.6 % (121/1259) and the patients who suffered from postoperative SIRS had longer hospital stays and higher hospital costs (all p

Suggested Citation

  • Jingping Hu & Chaojin Chen & Xiaoyue Li & Xiangyang Zang & Jie Ke & Shaoli Zhou & Haiyan Mai & Chulian Gong, 2024. "Risk of Systemic Inflammatory Response Syndrome Following Preoperative Glucocorticoids Administration in Patients After Percutaneous Nephrolithotomy: A Retrospective Cohort Study," Drug Safety, Springer, vol. 47(5), pages 465-474, May.
    • Handle: RePEc:spr:drugsa:v:47:y:2024:i:5:d:10.1007_s40264-024-01402-y
    DOI: 10.1007/s40264-024-01402-y
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