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Cardiovascular Toxicity of Immune Checkpoint Inhibitors: A Guide for Clinicians

Author

Listed:
  • Emanuel Raschi

    (University of Bologna)

  • Simone Rossi

    (IRCCS Istituto delle Scienze Neurologiche di Bologna
    University of Bologna)

  • Andrea Giglio

    (University of Bologna
    IRCCS Azienda Ospedaliero-Universitaria di Bologna)

  • Michele Fusaroli

    (University of Bologna)

  • Flavio Burgazzi

    (University of Bologna)

  • Rita Rinaldi

    (IRCCS Istituto delle Scienze Neurologiche di Bologna)

  • Luciano Potena

    (IRCCS Azienda Ospedaliero-Universitaria di Bologna)

Abstract

Immune checkpoint inhibitors (ICIs) have revolutionized the treatment and care of patients with cancer owing to unique features, including the occurrence of the so-called immune-related adverse events (irAEs). A multidisciplinary team, possibly including a cardio-oncology specialist, is warranted to achieve a favorable patient outcome. Cardiovascular toxicity, especially myocarditis, emerged as a life-threatening irAE in the real-word setting, and the European Society of Cardiology has recently published the first guideline on cardio-oncology to increase awareness and promote a standardized approach to tackle this complex multimodal issue, including diagnostic challenges, assessment, treatment, and surveillance of patients with cancer receiving ICIs. In this article, through a question & answer format made up of case vignettes, we offer a clinically oriented overview on the latest advancements of ICI-related cardiovascular toxicity, focusing on myocarditis and associated irAEs (myositis and myasthenia gravis within the so-called overlap syndrome), with the purpose of assisting clinicians and healthcare professionals in daily clinical practice.

Suggested Citation

  • Emanuel Raschi & Simone Rossi & Andrea Giglio & Michele Fusaroli & Flavio Burgazzi & Rita Rinaldi & Luciano Potena, 2023. "Cardiovascular Toxicity of Immune Checkpoint Inhibitors: A Guide for Clinicians," Drug Safety, Springer, vol. 46(9), pages 819-833, September.
    • Handle: RePEc:spr:drugsa:v:46:y:2023:i:9:d:10.1007_s40264-023-01320-5
    DOI: 10.1007/s40264-023-01320-5
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