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Weight Gain During Antipsychotic Treatment in Children, Adolescents, and Adults: A Disproportionality Analysis in the Global Pharmacovigilance Database, Vigibase®

Author

Listed:
  • Florentia Kaguelidou

    (Robert Debre Hospital, Paris Cité University
    Hôpital Robert Debré
    Paris Cité University)

  • Zaba Valtuille

    (Robert Debre Hospital, Paris Cité University
    Hôpital Robert Debré)

  • Geneviève Durrieu

    (Toulouse University Hospital (CHU)
    Toulouse University Hospital)

  • Richard Delorme

    (Paris Cité University
    Institut Pasteur)

  • Hugo Peyre

    (Paris Cité University
    Institut Pasteur)

  • Jean-Marc Treluyer

    (Paris Cité University
    AP-HP Centre-Paris Cité University)

  • François Montastruc

    (Toulouse University Hospital (CHU)
    Toulouse University Hospital)

  • Laurent Chouchana

    (Paris Cité University
    AP-HP Centre-Paris Cité University)

Abstract

Introduction While antipsychotic-induced weight gain has been widely described in adults, it has yet to be better characterized in children and adolescents. Objective The aim of this study was to assess antipsychotic-induced weight-gain reporting in children and adolescents as compared to adults, and according to the type of antipsychotic. Methods The study is an observational, case–non-case study using individual case safety reports from the WHO global pharmacovigilance database VigiBase® from 1 January 2000 to 2 June 2021. Disproportionality in antipsychotic-related weight-gain reporting in children and adolescents compared to adults was evaluated based on reporting odds ratios (RORs) with corresponding 95% confidence intervals (CIs) through multivariate logistic regression modeling. Analysis was adjusted for sex, region of reporting, year of notification, reporter qualification, concomitant use of antidepressants, and use of more than one antipsychotic. Results Among 282,224 antipsychotic-related spontaneous reports included in this analysis, we identified 16,881 (6.0%) weight-gain cases. Disproportionality in weight-gain reporting was found in children (adjusted ROR (aROR) 3.6; 95% CI 3.3–3.8) and in adolescents (aROR 2.3; 95% CI 2.2–2.4) compared to adults. Use of risperidone was associated with the highest increase in weight-gain reporting in children (aROR 4.9; 95% CI 3.9–6.1) and adolescents (aROR 3.6; 95% CI 3.1–4.1). Conclusions Compared to adults, weight-gain reporting with antipsychotics was disproportionally higher in the pediatric population, especially in children under 12 years of age. Considering the impact of weight gain on global morbidity and mortality, physicians should closely monitor weight gain in young patients, especially children on risperidone.

Suggested Citation

  • Florentia Kaguelidou & Zaba Valtuille & Geneviève Durrieu & Richard Delorme & Hugo Peyre & Jean-Marc Treluyer & François Montastruc & Laurent Chouchana, 2023. "Weight Gain During Antipsychotic Treatment in Children, Adolescents, and Adults: A Disproportionality Analysis in the Global Pharmacovigilance Database, Vigibase®," Drug Safety, Springer, vol. 46(1), pages 77-85, January.
    • Handle: RePEc:spr:drugsa:v:46:y:2023:i:1:d:10.1007_s40264-022-01252-6
    DOI: 10.1007/s40264-022-01252-6
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    References listed on IDEAS

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    1. Lovisa Sandberg & Henric Taavola & Yasunori Aoki & Rebecca Chandler & G. Niklas Norén, 2020. "Risk Factor Considerations in Statistical Signal Detection: Using Subgroup Disproportionality to Uncover Risk Groups for Adverse Drug Reactions in VigiBase," Drug Safety, Springer, vol. 43(10), pages 999-1009, October.
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