IDEAS home Printed from https://ideas.repec.org/a/spr/drugsa/v45y2022i7d10.1007_s40264-022-01181-4.html
   My bibliography  Save this article

Incidence, Pathogenesis, and Management of Proton Pump Inhibitor-Induced Nephrotoxicity

Author

Listed:
  • Xiao Wei

    (The First Affiliated Hospital of Anhui Medical University
    First Affiliated Hospital of Anhui Medical University)

  • Jun Yu

    (Anhui Medical University)

  • Zhengkun Xu

    (Anhui Medical University)

  • Chun Wang

    (Anhui Medical University)

  • Yonggui Wu

    (The First Affiliated Hospital of Anhui Medical University)

Abstract

Proton pump inhibitors are widely used in the treatment of various acid-related diseases and are among the most commonly used drugs. Studies estimate that 25–70% of proton pump inhibitors are prescribed for inappropriate treatments, doses, and indications, where the benefits of proton pump inhibitor use may be less than the risk of adverse drug reactions for many patients. Acute interstitial nephritis is an immune-mediated atypical kidney injury in the long-term use of proton pump inhibitors that causes problems for clinicians and patients. In this review, we summarize the current knowledge of proton pump inhibitors inducing acute interstitial nephritis, chronic kidney disease, and even end-stage renal disease in terms of incidence, pathogenesis, factors, clinical features, and diagnosis. We discuss how these factors change under conditions of acute interstitial nephritis, chronic kidney disease, and end-stage renal disease. The purpose of this review is to assess the current evidence to help clinicians and patients interpret the potential causal relationship between proton pump inhibitor intake and nephrotoxicity. This prompts clinicians to consider the appropriate dose and duration of proton pump inhibitor therapy to avoid inappropriate use.

Suggested Citation

  • Xiao Wei & Jun Yu & Zhengkun Xu & Chun Wang & Yonggui Wu, 2022. "Incidence, Pathogenesis, and Management of Proton Pump Inhibitor-Induced Nephrotoxicity," Drug Safety, Springer, vol. 45(7), pages 703-712, July.
  • Handle: RePEc:spr:drugsa:v:45:y:2022:i:7:d:10.1007_s40264-022-01181-4
    DOI: 10.1007/s40264-022-01181-4
    as

    Download full text from publisher

    File URL: http://link.springer.com/10.1007/s40264-022-01181-4
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.

    File URL: https://libkey.io/10.1007/s40264-022-01181-4?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    References listed on IDEAS

    as
    1. Henrik Svanström & Marie Lund & Mads Melbye & Björn Pasternak, 2018. "Use of Proton Pump Inhibitors and the Risk of Acute Kidney Injury Among Patients with Rheumatoid Arthritis: Cohort Study," Drug Safety, Springer, vol. 41(8), pages 817-826, August.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.

      More about this item

      Statistics

      Access and download statistics

      Corrections

      All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:spr:drugsa:v:45:y:2022:i:7:d:10.1007_s40264-022-01181-4. See general information about how to correct material in RePEc.

      If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

      If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

      If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

      For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.springer.com/economics/journal/40264 .

      Please note that corrections may take a couple of weeks to filter through the various RePEc services.

      IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.