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Therapeutic Management of Idiosyncratic Drug-Induced Liver Injury and Acetaminophen Hepatotoxicity in the Paediatric Population: A Systematic Review

Author

Listed:
  • Hao Niu

    (Universidad de Málaga
    Carlos III Health Institute
    Platform for Clinical Research and Clinical Trials IBIMA, Plataforma Isciii De Investigación Clínica)

  • Edmond Atallah

    (University of Nottingham
    Nottingham University Hospitals NHS Trust and the University of Nottingham)

  • Ismael Alvarez-Alvarez

    (Universidad de Málaga
    Carlos III Health Institute
    Platform for Clinical Research and Clinical Trials IBIMA, Plataforma Isciii De Investigación Clínica)

  • Inmaculada Medina-Caliz

    (Universidad de Málaga)

  • Guruprasad P. Aithal

    (University of Nottingham
    Nottingham University Hospitals NHS Trust and the University of Nottingham)

  • Cigdem Arikan

    (Koç University
    Koç University Research Center for Translational Medicine (KUTTAM)-Liver Immunology Lab)

  • Raul J. Andrade

    (Universidad de Málaga
    Carlos III Health Institute)

  • M. Isabel Lucena

    (Universidad de Málaga
    Carlos III Health Institute
    Platform for Clinical Research and Clinical Trials IBIMA, Plataforma Isciii De Investigación Clínica
    Universidad de Málaga)

Abstract

Introduction Drug-induced liver injury (DILI) is a rare but serious adverse event that can progress to acute liver failure (ALF). The evidence for treatment of DILI in children is scarce. Objective We aimed to comprehensively review the available literature on the therapies for both acetaminophen overdose (APAP) and idiosyncratic DILI in the paediatric population. Methods We included original articles conducted in a paediatric population (

Suggested Citation

  • Hao Niu & Edmond Atallah & Ismael Alvarez-Alvarez & Inmaculada Medina-Caliz & Guruprasad P. Aithal & Cigdem Arikan & Raul J. Andrade & M. Isabel Lucena, 2022. "Therapeutic Management of Idiosyncratic Drug-Induced Liver Injury and Acetaminophen Hepatotoxicity in the Paediatric Population: A Systematic Review," Drug Safety, Springer, vol. 45(11), pages 1329-1348, November.
    • Handle: RePEc:spr:drugsa:v:45:y:2022:i:11:d:10.1007_s40264-022-01224-w
    DOI: 10.1007/s40264-022-01224-w
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