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Real-World Fetal Exposure to Acne Treatments in the United States: A Retrospective Analysis from 2006 to 2015

Author

Listed:
  • Yasser Albogami

    (University of Florida
    King Saud University
    University of Florida College of Pharmacy)

  • Amir Sarayani

    (University of Florida
    University of Florida College of Pharmacy)

  • Juan M. Hincapie-Castillo

    (University of Florida
    University of Florida College of Pharmacy)

  • Almut G. Winterstein

    (University of Florida
    University of Florida College of Pharmacy)

Abstract

Introduction Several studies have evaluated the effects of changes in isotretinoin risk mitigation programs, but little is known about actual fetal exposure rates in the context of other acne treatments. Objective Our objective was to quantify fetal exposure rates during the use of common acne treatments. Methods Employing the insurance claims data of > 100,000 acne treatment users between 2006 and 2015, we created three user cohorts: (1) isotretinoin (strong teratogen/mandatory risk mitigation program), (2) doxycycline/minocycline (mild teratogen, label warning), and (3) topical clindamycin/erythromycin (no fetal risk). Fetal exposure rates overall and stratified by age were compared after adjusting for potential confounders. Results Contraceptive use during acne treatment was

Suggested Citation

  • Yasser Albogami & Amir Sarayani & Juan M. Hincapie-Castillo & Almut G. Winterstein, 2021. "Real-World Fetal Exposure to Acne Treatments in the United States: A Retrospective Analysis from 2006 to 2015," Drug Safety, Springer, vol. 44(4), pages 447-454, April.
    • Handle: RePEc:spr:drugsa:v:44:y:2021:i:4:d:10.1007_s40264-021-01053-3
    DOI: 10.1007/s40264-021-01053-3
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