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Drug-Induced Hypophosphatemia: Current Insights

Author

Listed:
  • Efstathia Megapanou

    (University of Ioannina)

  • Matilda Florentin

    (University of Ioannina)

  • Haralampos Milionis

    (University of Ioannina)

  • Moses Elisaf

    (University of Ioannina)

  • George Liamis

    (University of Ioannina)

Abstract

Phosphate is actively involved in many important biochemical pathways, such as energy and nucleic acid metabolism, cellular signaling, and bone formation. Hypophosphatemia, defined as serum phosphate levels below 2.5 mg/dL (0.81 mmol/L), is frequently observed in the course of treatment with commonly used drugs, such as diuretics, bisphosphonates, antibiotics, insulin, and antacids. Furthermore, this undesired effect may complicate the use of several novel medications, including teriparatide, denosumab, parenteral iron, and antiviral and antineoplastic agents. This review addresses drug-associated hypophosphatemia, focusing on underlying mechanisms and the most recent knowledge on this topic, in order to increase the insight of clinicians, with reference to early diagnosis and appropriate management.

Suggested Citation

  • Efstathia Megapanou & Matilda Florentin & Haralampos Milionis & Moses Elisaf & George Liamis, 2020. "Drug-Induced Hypophosphatemia: Current Insights," Drug Safety, Springer, vol. 43(3), pages 197-210, March.
    • Handle: RePEc:spr:drugsa:v:43:y:2020:i:3:d:10.1007_s40264-019-00888-1
    DOI: 10.1007/s40264-019-00888-1
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