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Identifying Data Elements to Measure Frailty in a Dutch Nationwide Electronic Medical Record Database for Use in Postmarketing Safety Evaluation: An Exploratory Study

Author

Listed:
  • Janet Sultana

    (University of Messina
    Erasmus Medical Centre)

  • Ingrid Leal

    (Erasmus Medical Centre)

  • Marcel Wilde

    (Erasmus Medical Centre)

  • Maria Ridder

    (Erasmus Medical Centre)

  • Johan Lei

    (Erasmus Medical Centre)

  • Miriam Sturkenboom

    (Julius Centre for Global Health, Utrecht University Medical Centre)

  • Gianluca Trifiro’

    (University of Messina
    Erasmus Medical Centre)

Abstract

Introduction The role of frailty in postmarketing drug safety is increasingly acknowledged. Few European electronic medical records (EMRs) have been used to explore frailty in observational drug safety research. Objective The aim of this study was to identify data elements, beyond multimorbidity and polypharmacy, that could potentially contribute to measuring frailty among older adults in the Dutch nationwide Integrated Primary Care Information (IPCI) database. Methods Persons aged between 65 and 90 years in the IPCI database were identified from 2008 to 2013. Clinical non-disease, non-drug measurements that could potentially contribute to measuring frailty were identified and selected if they were recorded in > 0.005% of patients and could be included in at least one of three definitions of frailty: the frailty phenotype model, the cumulative deficit model, and direct evaluations of frailty through standardized frailty scores. The frequency of these measures was calculated. Results Overall, 314,191 (17% of the source population) elderly persons were identified. Of these, 7948 (2.53%) had one or more of 12 clinical measurements identified that could potentially contribute to measuring frailty, such as clinical evaluations of cognition, mobility, and cachexia, as well as direct measures of frailty, such as the Groningen Frailty Index. Three of five measurements required for the frailty phenotype were identified in

Suggested Citation

  • Janet Sultana & Ingrid Leal & Marcel Wilde & Maria Ridder & Johan Lei & Miriam Sturkenboom & Gianluca Trifiro’, 2019. "Identifying Data Elements to Measure Frailty in a Dutch Nationwide Electronic Medical Record Database for Use in Postmarketing Safety Evaluation: An Exploratory Study," Drug Safety, Springer, vol. 42(6), pages 713-719, June.
    • Handle: RePEc:spr:drugsa:v:42:y:2019:i:6:d:10.1007_s40264-018-00785-z
    DOI: 10.1007/s40264-018-00785-z
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    Cited by:

    1. Martin Gulliford, 2019. "Frailty and Drug Safety at Older Ages," Drug Safety, Springer, vol. 42(6), pages 699-700, June.

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