Author
Listed:
- Justine Benevent
(Faculté de Médecine de Toulouse
Centre Hospitalier Universitaire de Toulouse
INSERM, UMR 1027, Faculté de Médecine de Toulouse)
- Caroline Hurault-Delarue
(Centre Hospitalier Universitaire de Toulouse)
- Mélanie Araujo
(Centre Hospitalier Universitaire de Toulouse)
- Jean-Louis Montastruc
(Faculté de Médecine de Toulouse
Centre Hospitalier Universitaire de Toulouse
INSERM, UMR 1027, Faculté de Médecine de Toulouse
Centre Hospitalier Universitaire de Toulouse)
- Isabelle Lacroix
(Centre Hospitalier Universitaire de Toulouse)
- Christine Damase-Michel
(Faculté de Médecine de Toulouse
Centre Hospitalier Universitaire de Toulouse
INSERM, UMR 1027, Faculté de Médecine de Toulouse)
Abstract
Introduction The POMME (PrescriptiOn Médicaments Mères Enfants) cohort has been implemented for the evaluation of the long-term consequences of medicine prenatal exposure. It holds anonymous medical information as well as information on medicine and healthcare reimbursement to the children, from the first day of intra-uterine life until childhood. Objective This article provides a description of the cohort regarding its structure and content and presents an outlook of the studies that could be performed with this new data source. Methods Data sources include (1) the French Health Insurance Database (medicines and medical care prescriptions and reimbursements to children and mothers during pregnancy) and (2) the Mother and Child Protection Centre Database (child health certificates at birth, 9 months of age and 24 months of age). Children born in Haute-Garonne (south-west France), over a period of 1 year (from 1 July to 30 June), are registered in POMME every 5 years. The cohort began on 1 July, 2010. Results To date, 8372 children have been recorded in POMME. They have reached 7 years of age now. Among them, 4249 (50.8%) are boys, 286 (3.4%) were from multiple pregnancies and 519 (6.2%) were born prematurely. They were prenatally exposed to 9.8 ± 6.1 medications. After birth, drug exposure was greatest in children aged 0–2 years. Children were mostly exposed to paracetamol, anti-infective agents and respiratory system drugs; 908 (10.8%) children presented with at least two signs of psychomotor development disorders. Conclusions POMME provides an observatory study on drug exposure and medical care use in children. This innovative cohort would make it possible to assess the risk of the long-term consequences of prenatal medicine exposure.
Suggested Citation
Justine Benevent & Caroline Hurault-Delarue & Mélanie Araujo & Jean-Louis Montastruc & Isabelle Lacroix & Christine Damase-Michel, 2019.
"POMME: The New Cohort to Evaluate Long-Term Effects After Prenatal Medicine Exposure,"
Drug Safety, Springer, vol. 42(1), pages 45-54, January.
Handle:
RePEc:spr:drugsa:v:42:y:2019:i:1:d:10.1007_s40264-018-0712-9
DOI: 10.1007/s40264-018-0712-9
Download full text from publisher
As the access to this document is restricted, you may want to search for a different version of it.
Corrections
All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:spr:drugsa:v:42:y:2019:i:1:d:10.1007_s40264-018-0712-9. See general information about how to correct material in RePEc.
If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.
We have no bibliographic references for this item. You can help adding them by using this form .
If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.
For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.springer.com/economics/journal/40264 .
Please note that corrections may take a couple of weeks to filter through
the various RePEc services.