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Use of Antihypertensive Drugs and Risk of Malignant Melanoma: A Meta-analysis of Observational Studies

Author

Listed:
  • Huilin Tang

    (Indiana University
    Indiana University
    Peking University Third Hospital)

  • Shuangshuang Fu

    (The University of Texas Health Science Center at Houston)

  • Suodi Zhai

    (Peking University Third Hospital)

  • Yiqing Song

    (Indiana University
    Indiana University)

  • Jiali Han

    (Indiana University
    Indiana University
    Indiana University)

Abstract

Introduction Several antihypertensive drugs are photosensitizing and may promote the development of malignant melanoma (MM), but evidence remains inconsistent. We sought to quantify the association between use of antihypertensive drugs and MM risk. Methods We systematically searched PubMed, Embase, and CENTRAL from inception to August 17, 2017 to identify observational studies that reported the MM risk associated with the use of antihypertensive drugs. A random-effects meta-analysis was used to estimate the odds ratio (OR) with 95% confidence interval (CI). Results Overall, we included eight observational studies (two cohort studies and six case–control studies). Compared with non-use, use of diuretics (OR 1.10; 95% CI 1.03–1.17) or β-adrenergic blocking agents (OR 1.19; 95% CI 1.04–1.37) was significantly associated with increased risk of MM. The use of angiotensin-converting enzyme inhibitors (OR 1.08; 95% CI 0.95–1.23), angiotensin II receptor blockers (OR 1.12; 95% CI 0.95–1.31), and calcium channel blockers (OR 1.12; 95% CI 0.72–1.74) was not significantly associated with increased risk of MM. Conclusions Current evidence from observational studies suggests that use of diuretics or β-adrenergic blocking agents may be associated with increased risk of MM. Further large well-conducted prospective studies are required to confirm our findings.

Suggested Citation

  • Huilin Tang & Shuangshuang Fu & Suodi Zhai & Yiqing Song & Jiali Han, 2018. "Use of Antihypertensive Drugs and Risk of Malignant Melanoma: A Meta-analysis of Observational Studies," Drug Safety, Springer, vol. 41(2), pages 161-169, February.
    • Handle: RePEc:spr:drugsa:v:41:y:2018:i:2:d:10.1007_s40264-017-0599-x
    DOI: 10.1007/s40264-017-0599-x
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    1. Beatrice Nardone & Sara Majewski & Ashley S. Kim & Tina Kiguradze & Estela M. Martinez-Escala & Rivka Friedland & Ahmad Amin & Anne E. Laumann & Beatrice J. Edwards & Alfred W. Rademaker & Mary C. Mar, 2017. "Melanoma and Non-Melanoma Skin Cancer Associated with Angiotensin-Converting-Enzyme Inhibitors, Angiotensin-Receptor Blockers and Thiazides: A Matched Cohort Study," Drug Safety, Springer, vol. 40(3), pages 249-255, March.
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