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Comorbid Social Phobia and Major Depressive Disorder: the Influence of Remission from Depression on Quality of Life and Functioning

Author

Listed:
  • Alexander Joseph Steiner

    (Department of Psychology, California School of Professional Psychology at Alliant International University
    Department of Psychiatry and Behavioral Neurosciences, Cedars-Sinai Medical Center)

  • Stephanie Marie Wright

    (Department of Psychology, California School of Professional Psychology at Alliant International University)

  • Taylor Kuhn

    (University of California Los Angeles)

  • Waguih William IsHak

    (Department of Psychiatry and Behavioral Neurosciences, Cedars-Sinai Medical Center
    University of California Los Angeles)

Abstract

Social phobia (SP) and major depressive disorder (MDD) are frequently concurrent, which negatively affects quality of life (QOL), functioning, and depressive symptom severity. We hypothesized individuals with comorbid SP and MDD (MDD + SP) would have worse treatment outcomes than those with MDD alone (MDDnoSP), but that both groups would have significant responses to treatment, and those who achieved MDD remission would have the best increases in QOL and functioning. We analyzed data for 2280 adults who received citalopram monotherapy in phase 1 of the NIH-funded Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study. Participants (82 MDD + SP and 2198 MDDnoSP) with complete entry and exit scores across QOL, functioning, and depressive symptom severity were examined. MDD remission status following treatment was determined. Patient-reported QOL and functioning scores were classified as within-normal or severely-impaired. No significant between-group differences were observed across all outcomes at entry or exit. Both groups experienced significant improvements in QOL and functioning (all p values .77). Although non-significant, the MDD + SP group was more likely to achieve within-normal scores and MDD remission post-treatment. Findings were interesting as we initially expected the MDD + SP participants to have worse outcomes, yet those with MDD alone had a more chronic course. Regardless, participants who were able to achieve MDD remission post-treatment had significantly better improvements in QOL and functioning. Accordingly, researchers and clinicians should utilize QOL and functioning measures when examining treatment effectiveness, while also considering the role of remission from major depressive disorder on quality of life.

Suggested Citation

  • Alexander Joseph Steiner & Stephanie Marie Wright & Taylor Kuhn & Waguih William IsHak, 2017. "Comorbid Social Phobia and Major Depressive Disorder: the Influence of Remission from Depression on Quality of Life and Functioning," Applied Research in Quality of Life, Springer;International Society for Quality-of-Life Studies, vol. 12(3), pages 719-736, September.
    • Handle: RePEc:spr:ariqol:v:12:y:2017:i:3:d:10.1007_s11482-016-9485-4
    DOI: 10.1007/s11482-016-9485-4
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    Cited by:

    1. Christian WEISMAYER, 2022. "Applied Research in Quality of Life: A Computational Literature Review," Applied Research in Quality of Life, Springer;International Society for Quality-of-Life Studies, vol. 17(3), pages 1433-1458, June.

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