IDEAS home Printed from https://ideas.repec.org/a/spr/aphecp/v21y2023i6d10.1007_s40258-023-00833-5.html
   My bibliography  Save this article

Economic Evaluations of Imaging Biomarker-Driven Companion Diagnostics for Cancer: A Systematic Review

Author

Listed:
  • Sibo Liu

    (Duke‐NUS Medical School)

  • Daniel SW Tan

    (National Cancer Centre Singapore)

  • Nicholas Graves

    (Duke‐NUS Medical School)

  • Ann-Marie Chacko

    (National Cancer Centre Singapore
    Duke-NUS Medical School)

Abstract

Introduction There is a boom in imaging biomarker-driven companion and complementary diagnostics (CDx) for cancer, which brings opportunity for personalized medicine. Whether adoption of these technologies is likely to be cost-effective is a relevant question, and studies on this topic are emerging. Despite the growing number of economic evaluations, no review of the methods used, quality of reporting, and potential risk of bias has been done. We report a systematic review to identify, summarize, and critique the cost-effectiveness evidence for the use of biomarker-driven and imaging-based CDx to inform cancer treatments. Methods The Preferred Reporting Items of Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed. Systematic literature searches until 30 December 2022 were performed in PubMed, Web of Science, Medline, Embase, and Scopus for economic evaluations of imaging biomarker-based CDx for cancer. The inclusion and exclusion of studies were determined by pre-specified eligibility criteria informed by the ‘Patient, Intervention, Comparison, Outcome’ (PICO) framework. The Consolidated Health Economic Evaluation Reporting Standards (CHEERS) was used to assess the quality of reporting, and the Bias in Economic Evaluation (ECOBIAS) was used to examine the potential risk of bias of included studies. Results A total of 12 papers were included, with eight model-based and four trial-based studies. Implementing biomarker-driven, imaging-based CDx was reported to be cost-effective, cost saving, or dominant (cost saving and more effective) in ten papers. Inconsistent methods were found in the studies, and the quality of reporting was lacking against the CHEERS reporting guideline. Several potential sources of ‘risk of bias’ were identified. These should be acknowledged and carefully considered by researchers planning future health economic evaluations. Conclusion Despite favorable results towards the implementation of imaging biomarker-based CDx for cancer, there is room for improvement regarding the quantity and quality of economic evaluations, and that is expected as the awareness of current study limitations increases and more clinical data become available in the future.

Suggested Citation

  • Sibo Liu & Daniel SW Tan & Nicholas Graves & Ann-Marie Chacko, 2023. "Economic Evaluations of Imaging Biomarker-Driven Companion Diagnostics for Cancer: A Systematic Review," Applied Health Economics and Health Policy, Springer, vol. 21(6), pages 841-855, November.
    • Handle: RePEc:spr:aphecp:v:21:y:2023:i:6:d:10.1007_s40258-023-00833-5
    DOI: 10.1007/s40258-023-00833-5
    as

    Download full text from publisher

    File URL: http://link.springer.com/10.1007/s40258-023-00833-5
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1007/s40258-023-00833-5?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    References listed on IDEAS

    as
    1. Marike R. C. Hendriks & Maiwenn J. Al & Michel H. C. Bleijlevens & Jolanda C. M. van Haastregt & Harry F. J. M. Crebolder & Jacques Th. M. van Eijk & Silvia M. A. A. Evers, 2013. "Continuous versus Intermittent Data Collection of Health Care Utilization," Medical Decision Making, , vol. 33(8), pages 998-1008, November.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Nicola E Stanczyk & Eline S Smit & Daniela N Schulz & Hein de Vries & Catherine Bolman & Jean W M Muris & Silvia M A A Evers, 2014. "An Economic Evaluation of a Video- and Text-Based Computer-Tailored Intervention for Smoking Cessation: A Cost-Effectiveness and Cost-Utility Analysis of a Randomized Controlled Trial," PLOS ONE, Public Library of Science, vol. 9(10), pages 1-14, October.
    2. Irma H J Everink & Jolanda C M van Haastregt & Silvia M A A Evers & Gertrudis I J M Kempen & Jos M G A Schols, 2018. "An economic evaluation of an integrated care pathway in geriatric rehabilitation for older patients with complex health problems," PLOS ONE, Public Library of Science, vol. 13(2), pages 1-21, February.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:spr:aphecp:v:21:y:2023:i:6:d:10.1007_s40258-023-00833-5. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.springer.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.