IDEAS home Printed from https://ideas.repec.org/a/spr/aphecp/v20y2022i3d10.1007_s40258-022-00717-0.html
   My bibliography  Save this article

Cost Effectiveness of Pharmacological Management for Osteoarthritis: A Systematic Review

Author

Listed:
  • Jiayu Shi

    (Shanxi Medical University
    Shanxi Medical University Second Affiliated Hospital)

  • Kenan Fan

    (Shanxi Medical University
    Shanxi Medical University Second Affiliated Hospital)

  • Lei Yan

    (Shanxi Medical University Second Affiliated Hospital)

  • Zijuan Fan

    (Shanxi Medical University)

  • Fei Li

    (Shanxi Medical University)

  • Guishan Wang

    (Shanxi Medical University)

  • Haifeng Liu

    (Shanxi Medical University Second Affiliated Hospital)

  • Peidong Liu

    (Shanxi Medical University Second Affiliated Hospital)

  • Hongmei Yu

    (Shanxi Medical University)

  • Jiao Jiao Li

    (University of Technology Sydney)

  • Bin Wang

    (Shanxi Medical University Second Affiliated Hospital
    The First Affiliated Hospital, Zhejiang University School of Medicine)

Abstract

Background and objective Osteoarthritis (OA) is a highly prevalent, disabling disease requiring chronic management that is associated with an enormous individual and societal burden. This systematic review provides a global cost-effectiveness evaluation of pharmacological therapy for the management of OA. Methods Following Center for Reviews and Dissemination (CRD) guidance, a literature search strategy was undertaken using PubMed, EMBASE, Cochrane Library, Health Technology Assessment (HTA) database, and National Health Service Economic Evaluation database (NHS EED) to identify original articles containing cost-effectiveness evaluation of OA pharmacological treatment published before 4 November 2021. Risk of bias was assessed by two independent reviewers using the Joanna Briggs Institute (JBI) critical appraisal checklist for economic evaluations. The Quality of Health Economic Studies (QHES) instrument was used to assess the reporting quality of included articles. Results Database searches identified 43 cost-effectiveness analysis studies (CEAs) on pharmacological management of OA that were conducted in 18 countries and four continents, with one study containing multiple continents. A total of four classes of drugs were assessed, including non-steroidal anti-inflammatory drugs (NSAIDs), opioid analgesics, symptomatic slow-acting drugs for osteoarthritis (SYSADOAs), and intra-articular (IA) injections. The methodological approaches of these studies showed substantial heterogeneity. The incremental cost-effectiveness ratios (ICERs) per quality-adjusted life-year (QALY) were (in 2021 US dollars) US$44.40 to US$307,013.56 for NSAIDS, US$11,984.84 to US$128,028.74 for opioids, US$10,930.17 to US$27,799.73 for SYSADOAs, and US$258.36 to US$58,447.97 for IA injections in different continents. The key drivers of cost effectiveness included medical resources, productivity, relative risks, and selected comparators. Conclusion This review showed substantial heterogeneity among studies, ranging from a finding of dominance to very high ICERs, but most studies found interventions to be cost effective based on specific ICER thresholds. Important challenges in the analysis were related to the standardization and methodological quality of studies, as well as the presentation of results.

Suggested Citation

  • Jiayu Shi & Kenan Fan & Lei Yan & Zijuan Fan & Fei Li & Guishan Wang & Haifeng Liu & Peidong Liu & Hongmei Yu & Jiao Jiao Li & Bin Wang, 2022. "Cost Effectiveness of Pharmacological Management for Osteoarthritis: A Systematic Review," Applied Health Economics and Health Policy, Springer, vol. 20(3), pages 351-370, May.
    • Handle: RePEc:spr:aphecp:v:20:y:2022:i:3:d:10.1007_s40258-022-00717-0
    DOI: 10.1007/s40258-022-00717-0
    as

    Download full text from publisher

    File URL: http://link.springer.com/10.1007/s40258-022-00717-0
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1007/s40258-022-00717-0?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    References listed on IDEAS

    as
    1. Sherif Nasef & A. Shaaban & Joaquin Mould-Quevedo & Tarek Ismail, 2015. "The cost-effectiveness of celecoxib versus non-steroidal anti-inflammatory drugs plus proton-pump inhibitors in the treatment of osteoarthritis in Saudi Arabia," Health Economics Review, Springer, vol. 5(1), pages 1-8, December.
    2. Ronald Wielage & Julie Myers & Robert Klein & Michael Happich, 2013. "Cost-Effectiveness Analyses of Osteoarthritis Oral Therapies: a Systematic Review," Applied Health Economics and Health Policy, Springer, vol. 11(6), pages 593-618, December.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.

      More about this item

      Statistics

      Access and download statistics

      Corrections

      All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:spr:aphecp:v:20:y:2022:i:3:d:10.1007_s40258-022-00717-0. See general information about how to correct material in RePEc.

      If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

      If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

      If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

      For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.springer.com .

      Please note that corrections may take a couple of weeks to filter through the various RePEc services.

      IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.