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French Value-Set of the QLU-C10D, a Cancer-Specific Utility Measure Derived from the QLQ-C30


  • Virginie Nerich

    (University Hospital
    INSERM, EFS-BFC, UMR1098, University of Franche-Comté)

  • Eva Maria Gamper

    (Medical University of Innsbruck)

  • Richard Norman

    (Curtin University)

  • Madeleine King

    (University of Sydney
    University of Sydney)

  • Bernhard Holzner

    (Medical University of Innsbruck)

  • Rosalie Viney

    (UTS Business School University of Technology Sydney (UTS))

  • Georg Kemmler

    (Medical University of Innsbruck)


Background and objective The EORTC Quality of Life Utility Measure-Core 10 Dimensions (QLU-C10D) is a new multi-attribute utility instrument derived from the EORTC Quality of Life Questionnaire-Core 30 (QLQ-C30), a widely used cancer-specific quality-of-life questionnaire. It covers ten dimensions: physical, role functioning, social, emotional functioning, pain, fatigue, sleep, appetite, nausea and bowel problems. To allow national health preferences to be reflected, country-specific valuations are being performed through collaboration between the Multi-Attribute Utility Cancer (MAUCa) Consortium and the EORTC. The aim of this study was to determine the utility weights for health states in the French version of the QLU-C10D. Methods Valuations were run in a web-based setting in a general population sample of 1033 adults. Utilities were elicited using a discrete-choice experiment (DCE). Data were analyzed by conditional logistic regression and mixed logits. Results The sample was representative of the general French population in terms of gender and age. Dimensions with the largest impact on utility weights were, in this order: physical functioning, pain and emotional functioning. The impact on utilities was lower for role functioning, nausea, bowel problems and social functioning. The dimensions of sleep, fatigue and lacking appetite were associated with the smallest utility decrement. Conclusion The results of the present study provide utility weights for the QLU-C10D and offer interesting prospects, as some cancer-specific dimensions also received sizeable utility weights (nausea and bowel problems). In fact, the EQ-5D and the HUI 3 are recommended in France and commonly used for cancer-related CUA; however, both these instruments are generic. The availability of a new cancer-specific utility instrument, such as the QLU-C10D, could improve the quality and the pertinence of future CUA in oncology

Suggested Citation

  • Virginie Nerich & Eva Maria Gamper & Richard Norman & Madeleine King & Bernhard Holzner & Rosalie Viney & Georg Kemmler, 2021. "French Value-Set of the QLU-C10D, a Cancer-Specific Utility Measure Derived from the QLQ-C30," Applied Health Economics and Health Policy, Springer, vol. 19(2), pages 191-202, March.
  • Handle: RePEc:spr:aphecp:v:19:y:2021:i:2:d:10.1007_s40258-020-00598-1
    DOI: 10.1007/s40258-020-00598-1

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    References listed on IDEAS

    1. John Brazier & Simon Dixon, 1995. "The use of condition specific outcome measures in economic appraisal," Health Economics, John Wiley & Sons, Ltd., vol. 4(4), pages 255-264, July.
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    1. Journal round-up: Applied Health Economics and Health Policy 19(2)
      by karanshahk2 in The Academic Health Economists' Blog on 2021-04-19 06:00:07

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