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Assessment of Public Health and Economic Impact of Intranasal Live-Attenuated Influenza Vaccination of Children in France Using a Dynamic Transmission Model

Author

Listed:
  • L. Gerlier

    (QuintilesIMS Real-World Evidence Solutions)

  • M. Lamotte

    (QuintilesIMS Real-World Evidence Solutions)

  • S. Grenèche

    (AstraZeneca)

  • X. Lenne

    (University Lille Nord de France)

  • F. Carrat

    (Sorbonne Universités, UPMC Univ Paris 06, INSERM, Institut Pierre Louis d’épidémiologie et de Santé Publique (IPLESP UMRS 1136)
    Saint-Antoine Hospital, APHP)

  • C. Weil-Olivier

    (University Paris VII)

  • O. Damm

    (Bielefeld University)

  • M. Schwehm

    (ExploSYS GmbH)

  • M. Eichner

    (University of Tübingen
    Epimos GmbH)

Abstract

Objectives We estimated the epidemiological and economic impact of extending the French influenza vaccination programme from at-risk/elderly (≥65 years) only to healthy children (2–17 years). Methods A deterministic, age-structured, dynamic transmission model was used to simulate the transmission of influenza in the French population, using the current vaccination coverage with trivalent inactivated vaccine (TIV) in at-risk/elderly individuals (current strategy) or gradually extending the vaccination to healthy children (aged 2–17 years) with intranasal, quadrivalent live-attenuated influenza vaccine (QLAIV) from current uptake up to 50% (evaluated strategy). Epidemiological, medical resource use and cost data were taken from international literature and country-specific information. The model was calibrated to the observed numbers of influenza-like illness visits/year. The 10-year number of symptomatic cases of confirmed influenza and direct medical costs (‘all-payer’) were calculated for the 0–17- (direct and indirect effects) and ≥18-year-old (indirect effect). The incremental cost-effectiveness ratio (ICER) was calculated for the total population, using a 4% discount rate/year. Results Assuming 2.3 million visits/year and 1960 deaths/year, the model calibration yielded an all-year average basic reproduction number (R 0) of 1.27. In the population aged 0–17 years, QLAIV prevented 865,000 influenza cases/year (58.4%), preventing 10-year direct medical expenses of €374 million. In those aged ≥18 years with unchanged TIV coverage, 1.2 million cases/year were averted (27.6%) via indirect effects (additionally prevented expenses, €457 million). On average, 613 influenza-related deaths were averted annually overall. The ICER was €18,001/life-year gained. The evaluated strategy had a 98% probability of being cost-effective at a €31,000/life-year gained threshold. Conclusions The model demonstrated strong direct and indirect benefits of protecting healthy children against influenza with QLAIV on public health and economic outcomes in France.

Suggested Citation

  • L. Gerlier & M. Lamotte & S. Grenèche & X. Lenne & F. Carrat & C. Weil-Olivier & O. Damm & M. Schwehm & M. Eichner, 2017. "Assessment of Public Health and Economic Impact of Intranasal Live-Attenuated Influenza Vaccination of Children in France Using a Dynamic Transmission Model," Applied Health Economics and Health Policy, Springer, vol. 15(2), pages 261-276, April.
  • Handle: RePEc:spr:aphecp:v:15:y:2017:i:2:d:10.1007_s40258-016-0296-4
    DOI: 10.1007/s40258-016-0296-4
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    Cited by:

    1. Yun-Kyung Kim & Joon Young Song & Hyeongap Jang & Tae Hyun Kim & Heejo Koo & Lijoy Varghese & Euna Han, 2018. "Cost Effectiveness of Quadrivalent Influenza Vaccines Compared with Trivalent Influenza Vaccines in Young Children and Older Adults in Korea," PharmacoEconomics, Springer, vol. 36(12), pages 1475-1490, December.

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