IDEAS home Printed from https://ideas.repec.org/a/spr/aodasc/v3y2016i3d10.1007_s40745-016-0085-9.html
   My bibliography  Save this article

Joint Modeling of Longitudinal CD4 Count and Weight Measurements of HIV/Tuberculosis Co-infected Patients at Jimma University Specialized Hospital

Author

Listed:
  • Aboma Temesgen

    (Haramaya University)

  • Teshome Kebede

    (Haramaya University)

Abstract

As HIV/TB co-infected patients are started to be visited, it is common to measure weight and CD4 repeatedly overtime to determine the health status of patients. Most of the time linear mixed modeling of weight and CD4 count cannot handle the association between the outcomes whereas the joint modeling of multivariate linear mixed model does. Thus, this study was an attempt to model jointly the longitudinal CD4 and weight measurements of HIV/TB co-infected patients. This retrospective study consists of 254 HIV/TB co-infected patients who were 18 years old and above, and on ART followup from 1st February 2009 to 1st July 2014 at Jimma University Specialized Hospital. Firstly, weight and square root of CD4 count were analyzed separately. Based on the separate model, the joint models were built to know the correlation between mean change of weight and CD4 count overtime. Finally, appropriate model was selected based on AIC and BIC values. The fit statistics showed that the joint model fitted the data better than the separate model. From the joint model sex, educational level and functional status were the factors contributing to the prediction of HIV/TB co-infected patients weight at baseline. Beside the linear time effect has a positive effect on the mean change of weight whereas the quadratic time change has negative effect. The baseline CD4 count was differ by patient status and functional status. Further, the linear time effect has a positive sign and found to be statistically significant at 5 % level of significance on the mean change of the square root of CD4 count. Nevertheless, the quadratic time effect has a significant negative effect. The finding of the current study revealed that there was a moderate positive association between the mean change of weight and square root of CD4 count overtime.

Suggested Citation

  • Aboma Temesgen & Teshome Kebede, 2016. "Joint Modeling of Longitudinal CD4 Count and Weight Measurements of HIV/Tuberculosis Co-infected Patients at Jimma University Specialized Hospital," Annals of Data Science, Springer, vol. 3(3), pages 321-338, September.
    • Handle: RePEc:spr:aodasc:v:3:y:2016:i:3:d:10.1007_s40745-016-0085-9
    DOI: 10.1007/s40745-016-0085-9
    as

    Download full text from publisher

    File URL: http://link.springer.com/10.1007/s40745-016-0085-9
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1007/s40745-016-0085-9?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:spr:aodasc:v:3:y:2016:i:3:d:10.1007_s40745-016-0085-9. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.springer.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.