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Health Utilities in People with Hepatitis C Virus Infection: A Study Using Real-World Population-Level Data

Author

Listed:
  • Yasmin A. Saeed

    (Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON, Canada
    Toronto Health Economics and Technology Assessment (THETA) Collaborative, University Health Network, Toronto, ON, Canada
    ICES, Toronto, ON, Canada
    School of Pharmacy, University of Waterloo, Kitchener, Ontario, Canada)

  • Nicholas Mitsakakis

    (Children’s Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada)

  • Jordan J. Feld

    (Toronto Centre for Liver Disease, University Health Network, Toronto, ON, Canada)

  • Murray D. Krahn

    (Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON, Canada
    Toronto Health Economics and Technology Assessment (THETA) Collaborative, University Health Network, Toronto, ON, Canada
    ICES, Toronto, ON, Canada)

  • Jeffrey C. Kwong

    (ICES, Toronto, ON, Canada
    Public Health Ontario, Toronto, ON, Canada
    Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada
    Centre for Vaccine Preventable Diseases, University of Toronto, Toronto, ON, Canada)

  • William W. L. Wong

    (Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON, Canada
    Toronto Health Economics and Technology Assessment (THETA) Collaborative, University Health Network, Toronto, ON, Canada
    ICES, Toronto, ON, Canada
    School of Pharmacy, University of Waterloo, Kitchener, Ontario, Canada)

Abstract

Background Hepatitis C virus (HCV) infection is associated with reduced quality of life and health utility. It is unclear whether this is primarily due to HCV infection itself or commonly co-occurring patient characteristics such as low income and mental health issues. This study aims to estimate and separate the effects of HCV infection on health utility from the effects of clinical and sociodemographic factors using real-world population-level data. Methods We conducted a cross-sectional retrospective cohort study to estimate health utilities in people with and without HCV infection in Ontario, Canada, from 2000 to 2014 using linked survey data from the Canadian Community Health Survey and health administrative data. Utilities were derived from the Health Utilities Index Mark 3 instrument. We used propensity score matching and multivariable linear regression to examine the impact of HCV infection on utility scores while adjusting for clinical and sociodemographic factors. Results There were 7,102 individuals with hepatitis C status and health utility data available (506 HCV-positive, 6,596 HCV-negative). Factors associated with marginalization were more prevalent in the HCV-positive cohort (e.g., household income

Suggested Citation

  • Yasmin A. Saeed & Nicholas Mitsakakis & Jordan J. Feld & Murray D. Krahn & Jeffrey C. Kwong & William W. L. Wong, 2025. "Health Utilities in People with Hepatitis C Virus Infection: A Study Using Real-World Population-Level Data," Medical Decision Making, , vol. 45(3), pages 332-343, April.
    • Handle: RePEc:sae:medema:v:45:y:2025:i:3:p:332-343
    DOI: 10.1177/0272989X251319342
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