IDEAS home Printed from https://ideas.repec.org/a/sae/clnure/v34y2025i3-4p153-159.html
   My bibliography  Save this article

HIF-1A Gene Polymorphisms are Associated With Clinical and Biochemical Parameters in COVID-19 Patients in Serbian Population

Author

Listed:
  • Biljana Ljujic
  • Nela Maksimovic
  • Tatjana Damnjanovic
  • Ivana Novakovic
  • Milka Grk
  • Milica Gulic
  • Marija Dusanovic-Pjevic
  • Biljana Popovska Jovicic
  • Ivana Rakovic
  • Marina Gazdic Jankovic
  • Marina Miletic Kovacevic
  • Biljana Jekic

Abstract

The hypoxia-inducible factor-1 alpha (HIF-1 alpha) is a major regulator of adaptive response to hypoxia, common in patients with severe coronavirus disease 2019 (COVID-19). In addition, HIF-1 alpha regulates the expression of the most important proteins necessary for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection of cells. The study included 129 hospitalized COVID-19 patients. Genotypes of HIF-1A gene polymorphisms rs11549465 and rs2057482 were determined by the RT-PCR method. We have observed lower mean platelet counts in carriers of HIF-1A rs11549465CC genotype ( p  = .050) and a significant association of thrombocytopenia with rs11549465CC/rs2057482CT HIF-1A genotypes combination ( p  = .037) in the group of patients under the age of 40. HIF-1A rs11549465CC genotype and rs11549465CC/rs2057482CT genotype combination could be predictive markers for thrombocytopenia in COVID-19 patients. Identification of such predictive markers for severe disease may contribute to a more efficient response of health systems to the SARS-CoV-2 pandemic.

Suggested Citation

  • Biljana Ljujic & Nela Maksimovic & Tatjana Damnjanovic & Ivana Novakovic & Milka Grk & Milica Gulic & Marija Dusanovic-Pjevic & Biljana Popovska Jovicic & Ivana Rakovic & Marina Gazdic Jankovic & Mari, 2025. "HIF-1A Gene Polymorphisms are Associated With Clinical and Biochemical Parameters in COVID-19 Patients in Serbian Population," Clinical Nursing Research, , vol. 34(3-4), pages 153-159, May.
    • Handle: RePEc:sae:clnure:v:34:y:2025:i:3-4:p:153-159
    DOI: 10.1177/10547738241308972
    as

    Download full text from publisher

    File URL: https://journals.sagepub.com/doi/10.1177/10547738241308972
    Download Restriction: no
    File URL: https://libkey.io/10.1177/10547738241308972?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:sae:clnure:v:34:y:2025:i:3-4:p:153-159. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: SAGE Publications (email available below). General contact details of provider: .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.