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Impact of Fatigue on Subjective and Objective Cognitive Functions in Persons with Post-COVID-19 Condition

Author

Listed:
  • Gia Han Le
  • Angela T.H. Kwan
  • Ziji Guo
  • Donovan A. Dev
  • Sabrina Wong
  • Sebastian Badulescu
  • Felicia Ceban
  • Kayla M. Teopiz
  • Danica E. Johnson
  • Hartej Gill
  • Joshua D. Di Vincenzo
  • Shakila Meshkat
  • Taeho Greg Rhee
  • Roger Ho
  • Lee Phan
  • Joshua D. Rosenblat
  • Rodrigo B. Mansur
  • Mehala Subramaniapillai
  • Roger S. McIntyre

Abstract

Post-COVID-19 condition (PCC) is a serious debilitating condition that develops after the resolution of an acute infection of severe acute respiratory syndrome-associated coronavirus 2. Some commonly reported symptoms include fatigue and cognitive deficits. Multiple lines of evidence have indicated fatigue to be associated with cognitive deficits in the general population. Herein, we perform a secondary analysis of the effects of fatigue on subjective and objective cognition in persons with PCC using a generalized linear model. In this study, fatigue was measured using the Fatigue Severity Scale (FSS) and cognition was measured using the Digit-Symbol Substitution Test (DSST) and the Trails Making Test parts A and B (TMT-A/B). FSS had a statistically significant negative correlation with DSST and TMT-A/B scores. Fatigue serves as a possible target for the development of PCC therapeutics. Fatigue and cognition correlates should be further investigated for underlying neurobiological substrates in persons with PCC.

Suggested Citation

  • Gia Han Le & Angela T.H. Kwan & Ziji Guo & Donovan A. Dev & Sabrina Wong & Sebastian Badulescu & Felicia Ceban & Kayla M. Teopiz & Danica E. Johnson & Hartej Gill & Joshua D. Di Vincenzo & Shakila Mes, 2025. "Impact of Fatigue on Subjective and Objective Cognitive Functions in Persons with Post-COVID-19 Condition," Clinical Nursing Research, , vol. 34(3-4), pages 143-152, May.
    • Handle: RePEc:sae:clnure:v:34:y:2025:i:3-4:p:143-152
    DOI: 10.1177/10547738251329412
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    References listed on IDEAS

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    1. Tanja Müller & Miriam C. Klein-Flügge & Sanjay G. Manohar & Masud Husain & Matthew A. J. Apps, 2021. "Neural and computational mechanisms of momentary fatigue and persistence in effort-based choice," Nature Communications, Nature, vol. 12(1), pages 1-14, December.
    2. Sean L. Wu & Andrew N. Mertens & Yoshika S. Crider & Anna Nguyen & Nolan N. Pokpongkiat & Stephanie Djajadi & Anmol Seth & Michelle S. Hsiang & John M. Colford & Art Reingold & Benjamin F. Arnold & Al, 2020. "Substantial underestimation of SARS-CoV-2 infection in the United States," Nature Communications, Nature, vol. 11(1), pages 1-10, December.
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