IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0358335.html

Clinical characteristics and emergency department-based warning indicators of fulminant myocarditis in children

Author

Listed:
  • Lingzhu Huang
  • Jingbo Jiang
  • Ying Qi
  • Xiaoxin Deng
  • Weike Ma
  • Xiaozhou Chen
  • Ping Song

Abstract

Background: Fulminant myocarditis (FM) in children is associated with a high mortality rate, while its early clinical manifestations are often nonspecific. This study aimed to identify early warning indicators available at emergency department (ED) presentations to facilitate early recognition of children at high risk of FM. Methods: A retrospective analysis was conducted on 140 children with acute myocarditis admitted through the ED between 01/01/2015 and 31/12/2024. Patients were classified into acute non-fulminant myocarditis (ANFM) (n = 86) and FM (n = 54) groups. The least absolute shrinkage and selection operator (LASSO) regression was utilized to optimize variable selection, followed by multivariable logistic regression analysis to identify early warning indicators of FM. Results: Gastrointestinal symptoms were the most common clinical manifestation in children with FM (88.9%). Compared with the ANFM group, children with FM had lower serum sodium levels and higher lactate and myocardial injury marker levels (all P

Suggested Citation

  • Lingzhu Huang & Jingbo Jiang & Ying Qi & Xiaoxin Deng & Weike Ma & Xiaozhou Chen & Ping Song, 2026. "Clinical characteristics and emergency department-based warning indicators of fulminant myocarditis in children," PLOS ONE, Public Library of Science, vol. 21(9), pages 1-14, September.
    • Handle: RePEc:plo:pone00:0358335
    DOI: 10.1371/journal.pone.0358335
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0358335
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0358335&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0358335?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0358335. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.