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Factors associated with severe COVID-19 outcomes among adults with at least a primary vaccination schedule: A retrospective cohort study from Alberta, Canada

Author

Listed:
  • Sylvia Aponte-Hao
  • Huong Luu
  • Karen J B Martins
  • Jason R Randall
  • Lynora Saxinger
  • Elissa Rennert-May
  • Jenine Leal
  • Tyler Williamson
  • Amanda Wilson
  • Michelle Blake
  • Tianyi Lu
  • Shehzad M Iqbal
  • James A Mansi
  • Andre B Araujo
  • David Martin
  • Scott W Klarenbach

Abstract

Background: With a large proportion of adults in Canada vaccinated against SARS-CoV-2, it is important to identify who remain at risk for severe COVID-19 outcomes after primary vaccination and additional (booster) doses. Methods: Adults (≥18 years) who received at least a primary vaccination schedule between December 2020 and March 2023 in Alberta, Canada were identified through population-level administrative data. Factors associated with severe COVID-19 outcomes (COVID-19 related hospitalization or death) were examined using univariable and multivariable Cox proportional hazard models. Results: Among those who received a primary vaccination schedule (n = 2,639,731), 0.2% (n = 5,475) had ≥ 1 severe COVID-19 outcome. Factors associated with a greater risk of a severe COVID-19 outcome included older age (≥65 versus

Suggested Citation

  • Sylvia Aponte-Hao & Huong Luu & Karen J B Martins & Jason R Randall & Lynora Saxinger & Elissa Rennert-May & Jenine Leal & Tyler Williamson & Amanda Wilson & Michelle Blake & Tianyi Lu & Shehzad M Iqb, 2026. "Factors associated with severe COVID-19 outcomes among adults with at least a primary vaccination schedule: A retrospective cohort study from Alberta, Canada," PLOS ONE, Public Library of Science, vol. 21(8), pages 1-21, August.
    • Handle: RePEc:plo:pone00:0354822
    DOI: 10.1371/journal.pone.0354822
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