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Structure function relationships differ between optic neuritis and glaucoma with comparable optical coherence tomography findings

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  • Heesuk Kim
  • Mi Jeong Kim
  • Jihei Sara Lee
  • Chan Yun Kim
  • Hyoung Won Bae

Abstract

This retrospective study compared structure-function relationships between patients with optic neuritis (ON) and primary open-angle glaucoma (POAG), focusing on the extent of retinal nerve fiber layer (RNFL) and ganglion cell-inner plexiform layer (GCIPL) damage and its correlation with visual field (VF) defects. We included 194 patients (ON: 47; POAG: 147) referred to Yonsei University Severance Eye Hospital between 2017 and 2023. RNFL and GCIPL thickness, VF indices, and the relationship between structural and functional measures were assessed. Despite comparable RNFL and GCIPL thinning, ON demonstrated significantly better VF performance than POAG (mean deviation: −2.26 dB vs. −7.32 dB; VF index: 95.48% vs. 80.43%; both p

Suggested Citation

  • Heesuk Kim & Mi Jeong Kim & Jihei Sara Lee & Chan Yun Kim & Hyoung Won Bae, 2026. "Structure function relationships differ between optic neuritis and glaucoma with comparable optical coherence tomography findings," PLOS ONE, Public Library of Science, vol. 21(7), pages 1-16, July.
    • Handle: RePEc:plo:pone00:0353553
    DOI: 10.1371/journal.pone.0353553
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